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Article
Open AccessTFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis
Fatty liver is a highly heterogenous condition driven by various pathogenic factors in addition to the severity of steatosis. Protein insufficiency has been causally linked to fatty liver with incompletely def...
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Article
Open AccessIslet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes
The immune system of some genetically susceptible children can be triggered by certain environmental factors to produce islet autoantibodies (IA) against pancreatic β cells, which greatly increases their risk ...
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Article
Open AccessWestern-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model
The prevalence of maternal obesity is increasing in the United States. Offspring born to women with obesity or poor glycemic control have greater odds of becoming obese and develo** metabolic disease later i...
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Article
Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology
Cells in human milk are an untapped source, as potential “liquid breast biopsies”, of material for investigating lactation physiology in a non-invasive manner. We used single cell RNA sequencing (scRNA-seq) to...
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Article
Associations between the activity of placental nutrient-sensing pathways and neonatal and postnatal metabolic health: the ECHO Healthy Start cohort
Our hypothesis was that the activity of placental nutrient-sensing pathways is associated with adiposity and metabolic health in childhood.
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Article
Type 2 Diabetes in Youth: the Role of Early Life Exposures
This review examines the impact of early life exposures on glucose metabolism in the offspring and explores potential metabolic mechanisms leading to type 2 diabetes in childhood.
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Article
How can parental obesity promote OA across generations?
Obesity promotes osteoarthritis (OA) through complex and incompletely understood biomechanical, metabolic and inflammatory factors. New data in mice add to this complexity by showing that eating a high-fat die...
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Insulin Resistance in Pregnancy: Implications for Mother and Offspring
In normal pregnancy, maternal metabolism transforms to one characterized by insulin resistance (IR) to promote nutrient availability to the fetus while supporting maternal metabolic needs. The rising global ep...
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Article
Open AccessAuthor Correction: The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessThe gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD
Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early colonization of the infant ...
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Article
Open AccessModulations in the offspring gut microbiome are refractory to postnatal synbiotic supplementation among juvenile primates
We and others have previously shown that alterations in the mammalian gut microbiome are associated with diet, notably early life exposure to a maternal high fat diet (HFD). Here, we aimed to further these stu...
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Article
Open AccessAltered gene expression and metabolism in fetal umbilical cord mesenchymal stem cells correspond with differences in 5-month-old infant adiposity gain
The intrauterine period is a critical time wherein developmental exposure can influence risk for chronic disease including childhood obesity. Using umbilical cord-derived mesenchymal stem cells (uMSC) from off...
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Infant Adiposity is Independently Associated with a Maternal High Fat Diet but not Related to Niacin Intake: The Healthy Start Study
Objectives Over-nutrition during pregnancy resulting from maternal obesity or an unhealthy diet can lead to excess infant adiposity at birth. Specific dietary macro- and micronutrients ha...
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Article
Developmental origins of NAFLD: a womb with a clue
Exposure to maternal overnutrition or undernutrition increases susceptibility to NAFLD in childhood and hastens progression to NASH across the lifespan, especi...
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Article
Open AccessGenomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model
Maternal obesity contributes to an increased risk of lifelong morbidity and mortality for both the mother and her offspring. In order to better understand the molecular mechanisms underlying these risks, we pr...
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Article
Microbial transmission from mothers with obesity or diabetes to infants: an innovative opportunity to interrupt a vicious cycle
Maternal obesity and diabetes dramatically increase the long-term risk for obesity in the next generation, and pregnancy and lactation may be critical periods at which to aim primary prevention to break the ob...
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Testing the fuel-mediated hypothesis: maternal insulin resistance and glucose mediate the association between maternal and neonatal adiposity, the Healthy Start study
In women who are overweight or obese before or during pregnancy there is an associated risk of increased fetal growth and higher birthweight. The metabolic phenotype of the overweight/obese pregnant woman, cha...
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Article
Open AccessPreconception maternal nutrition: a multi-site randomized controlled trial
Research directed to optimizing maternal nutrition commencing prior to conception remains very limited, despite suggestive evidence of its importance in addition to ensuring an optimal nutrition environment in...
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Article
Developmental origins of nonalcoholic fatty liver disease
Obese pregnant women may transmit their metabolic phenotype to offspring, leading to a cycle of obesity and diabetes over generations. Early childhood obesity predicts nonalcoholic fatty liver disease (NAFLD),...
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Article
5.1 Women with Gestational Diabetes Randomized to a Low-Carbohydrate/Higher Fat Diet Demonstrate Greater Insulin Resistance and Infant Adiposity (73-OR)
Conventional diet therapy in women with gestational diabetes (GDM) has focused on restriction of carbohydrate (CHO), which typically results in greater fat intake. Diets higher in fat are known to promote insu...
