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  1. Article

    Acetylcholine Relaxation of Renal Artery and Nitric Oxide Synthase Activity of Renal Cortex Increase with Fetal and Postnatal Age

    Endothelium-derived nitric oxide (NO) regulates hemodynamics in the fetal kidney and modulates renal perfusion during postnatal maturation. We hypothesize that NO release by renal arteries increases with fetal...

    Loren P Thompson, Carl P Weiner in Pediatric Research (1996)

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  2. Article

    Aspen Perinatal Biology Conference: August 28–31, 2010

    Loren P Thompson, Michele Brochu, Joel S Caton, Jacob E Friedman in Pediatric Research (2010)

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  3. Article

    Chronic hypoxia increases peroxynitrite, MMP9 expression, and collagen accumulation in fetal guinea pig hearts

    Chronic hypoxia increases the expression of inducible nitric oxide synthase (iNOS) mRNA and protein levels in fetal guinea pig heart ventricles. Excessive generation of nitric oxide (NO) can induce nitrosative...

    LaShauna C. Evans, Hongshan Liu, Gerard A. Pinkas, Loren P. Thompson in Pediatric Research (2012)

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    Article

    Chronic Hypoxia Impairs Cytochrome Oxidase Activity Via Oxidative Stress in Selected Fetal Guinea Pig Organs

    We hypothesized that chronic hypoxia disrupts mitochondrial function via oxidative stress in fetal organs. Pregnant guinea pig sows were exposed to either normoxia or hypoxia (10.5% O2, 14 days) in the presence o...

    Yazan M. Al-Hasan, LaShauna C. Evans, Gerard A. Pinkas… in Reproductive Sciences (2013)

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    Article

    Differential Responses of Hippocampal Neurons and Astrocytes to Nicotine and Hypoxia in the Fetal Guinea Pig

    In utero exposure to cigarette smoke has severe consequences for the develo** fetus, including increased risk of birth complications and behavioral and learning disabilities later in life. Evidence from anim...

    Tamara Blutstein, Michael A. Castello, Shaun S. Viechweg… in Neurotoxicity Research (2013)

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    Article

    Chronic Hypoxia Inhibits Respiratory Complex IV Activity and Disrupts Mitochondrial Dynamics in the Fetal Guinea Pig Forebrain

    Mitochondrial dysfunction is an underlying cause of childhood neurological disease secondary to the crucial role of mitochondria in proper neurodevelopment. We hypothesized that chronic intrauterine hypoxia (H...

    Tabitha M. Quebedeaux, Hong Song, Jamiu Giwa-Otusajo… in Reproductive Sciences (2022)

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    Article

    Sex-Selective Increase of IGF-2 Expression in the Hypoxic Guinea Pig Placenta of Growth-Restricted Fetuses

    Chronic hypoxia can cause fetal growth restriction (FGR) through placental dysfunction. Insulin-like growth factors (IGFs), such as IGF-2, play a major role in preservation of placental growth and function. We...

    Emad A. Elsamadicy, Loren P. Thompson in Reproductive Sciences (2022)

  8. Article

    Open Access

    Effects of Gestational Hypoxia on PGC1α and Mitochondrial Acetylation in Fetal Guinea Pig Hearts

    Chronic intrauterine hypoxia is a significant pregnancy complication impacting fetal heart growth, metabolism, and mitochondrial function, contributing to cardiovascular programming of the offspring. PGC1α (pe...

    Hong Song, Loren P. Thompson in Reproductive Sciences (2023)

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  9. Article

    Open Access

    Nicotinamide Riboside, an NAD + Precursor, Protects Against Cardiac Mitochondrial Dysfunction in Fetal Guinea Pigs Exposed to Gestational Hypoxia

    Gestational hypoxia inhibits mitochondrial function in the fetal heart and placenta contributing to fetal growth restriction and organ dysfunction. NAD + deficiency may contribute to a metabolic deficit by inh...

    Loren P. Thompson, Hong Song, Jamie Hartnett in Reproductive Sciences (2024)

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