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Open AccessHigh-resolution spatiotemporal map**: a comprehensive view of eukaryotic cell cycle proteome dynamics
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Open AccessPARP1-DNA co-condensation: the driver of broken DNA repair
DNA double-strand break (DSB) sites that prevent the disjunction of broken DNA ends are formed through poly (ADP-ribose) (PAR) polymerase 1 (PARP1)-DNA co-... -
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The ASH1L-AS1-ASH1L axis controls NME1-mediated activation of the RAS signaling in gastric cancer
Gastric cancer (GC) is one of the most leading cause of malignancies. However, the molecular mechanisms underlying stomach carcinogenesis remain incompletely understood. Dysregulated genetic and epigenetic alt...
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Open AccessActivated STING: an ion channel to trigger non-interferon-related functions
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Open AccessRas homolog family member J (RHOJ): a key regulator of chemoresistance associated with epithelial-mesenchymal transition
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Open AccessDeciphering dynamic changes of the aging transcriptome with COVID-19 progression and convalescence in the human blood
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Open AccessThe loss of epigenetic information: not only consequences but a cause of mammalian aging
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Open AccessMotile cilia and microvillar: accomplices of SARS-CoV-2 in penetrating mucus barrier and infecting airway epithelium
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Open AccessThe fungal mycobiome: a new hallmark of cancer revealed by pan-cancer analyses
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Open AccessAlterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions
The global coronavirus disease 2019 (COVID-19) pandemic is currently ongoing. It is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A high proportion of COVID-19 patients exhibit gastro...
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Open AccessSARS-CoV-2 Omicron variant: recent progress and future perspectives
Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, there have been a few variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), one of which is the Omicron variant (...
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Open AccessNovel pyroptosis-independent functions of gasdermins
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Open AccessSTING, a critical contributor to SARS-CoV-2 immunopathology
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Open AccessThe way of SARS-CoV-2 vaccine development: success and challenges
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). To halt the pandemic, multiple SARS-CoV-2 vaccines have been developed and several ha...
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Open AccesscGAS-like receptors: new RNA sensors in Drosophila
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Open AccessLiquid–liquid phase separation in human health and diseases
Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomole...
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Open AccessCancer Environment Immunotherapy: targeting TGF-β finds its way towards tissue healing and vasculature remodeling
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Open AccessA systematic review of SARS-CoV-2 vaccine candidates
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging virus that is highly pathogenic and has caused the recent worldwide pandemic officially named coronavirus disease (COVID-19). Current...
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Open AccessGLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies
Cancer cells are usually characterized by hyperactive glucose metabolism, which can often lead to glucose scarcity; thus, alternative pathways to rewire cancer metabolism are required. Here, we demonstrated th...
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Open AccessAn effective platform for cancer immunotherapy: pooled knockin targeting for genome engineering