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Article
Fate map** of human glioblastoma reveals an invariant stem cell hierarchy
Human glioblastomas harbour a subpopulation of glioblastoma stem cells that drive tumorigenesis. However, the origin of intratumoural functional heterogeneity between glioblastoma cells remains poorly understo...
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Article
Open AccessModeling the process of human tumorigenesis
Modelling the genesis of human cancers is at a scientific turning point. Starting from primary sources of normal human cells, it is now possible to reproducibly generate several types of malignant cell populat...
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Chapter and Conference Paper
Designing a Collaborative Malaysian-Vietnamese Online Writing Project: A Design-Based Research
In Vietnam, academic writing is often developed through a formal instructional setting. Teaching ESL writing to undergraduates in Vietnamese universities is not always easy as instructors are often overloaded ...
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Article
Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells
The first formal evidence of the shared and independent ability of basal cells and luminal pro-genitors isolated from normal human mammary tissue and transduced with a single oncogene to initiate tumorigeneses...
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Article
Open AccessDNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts
Genomic and phenotypic analyses indicate extensive intra- as well as intertumoral heterogeneity in primary human malignant cell populations despite their clonal origin. Cellular DNA barcoding offers a powerful...
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Article
Integrin β3 links therapy resistance and cancer stem cell properties
Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Inte...
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Article
Genetic engineering of a Lemna isoleucine auxotroph
Lemna, a member of the Lemnaceae or duckweed family, is a small aquatic plant that can be quickly transformed to produce recombinant proteins in a contained and controlled bioprocessing environme...
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Article
Cancer stem cells: an evolving concept
There is increasing debate about what is meant by the term 'cancer stem cell' (CSC) and the degree to which the concept of CSCs can provide insights into cancer biology and therapy. This Timeline article trace...
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Article
Development and characterization of a generalized gene tagging system for higher plants using an engineered maize transposon Ac
This report describes a series of transposon tagging vectors for dicotyledonous plants based on the maize transposable element Ac. This binary system includes the transposase (Ts) and the tagging element (Ds) on ...
