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  1. No Access

    Article

    Activation of cDCs and iNKT cells contributes to triptolide-induced hepatotoxicity via STING signaling pathway and endoplasmic reticulum stress

    Triptolide (TP) exhibits therapeutic potential against multiple diseases. However, its application in clinics is limited by TP-induced hepatoxicity. TP can activate invariant natural killer T (iNKT) cells in t...

    **n Chen, Zixun Yu, Cheng Nong, Rufeng Xue, Mingxuan Zhang… in Cell Biology and Toxicology (2023)

  2. No Access

    Article

    SEW2871 attenuates ANIT-induced hepatotoxicity by protecting liver barrier function via sphingosine 1-phosphate receptor-1–mediated AMPK signaling pathway

    Cholestatic liver injury, a group of diseases characterized with dysregulated bile acid (BA) homeostasis, was partly resulted from BA circulation disorders, which is commonly associated with the damage of hepa...

    Tingting Yang, Xue Wang, Yi Zhou, Qiongna Yu, Cai Heng… in Cell Biology and Toxicology (2021)

  3. No Access

    Article

    Development and Evaluation of Topical Delivery of Microemulsions Containing Adapalene (MEs-Ap) for Acne

    The main objective of the study was to prepare the microemulsions containing adapalene (MEs-Ap) to enhance epidermal penetration, dermal retention, and local bioavailability compared with the commercial prepar...

    Bing Shao, Lixin Sun, Na Xu, Hongwei Gu, Hongyu Ji, Linhua Wu in AAPS PharmSciTech (2021)

  4. No Access

    Chapter

    Antitumor Effect of Ganoderma (Lingzhi) Mediated by Immunological Mechanism and Its Clinical Application

    The antitumor effect of Ganoderma (Lingzhi) is closely related to immunoregulation. Based on our research and other references, this article discussed the antitumor effect of Ganoderma mediated by immunological m...

    Zhibin Lin, Lixin Sun in Ganoderma and Health (2019)

  5. No Access

    Chapter

    Cellular and Molecular Mechanism of Ganoderma (Lingzhi) Against Tumor

    The anticancer potential of Ganoderma (Lingzhi) and its extracts has been widely demonstrated, including antiproliferative and apoptosis inductive, antimetastatic, antiangiogenic, and multidrug resistance reversi...

    Yu Sun, Lixin Sun in Ganoderma and Health (2019)

  6. No Access

    Article

    Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats

    Estrogen-induced cholestasis occurs in many women who are susceptible due to pregnancy or hormone replacement therapy for postmenopausal syndrome. 17α-Ethinylestradiol (EE), as a synthetic estrogen, has been w...

    **aojiaoyang Li, Run** Liu, Lan Luo, Linxi Yu, … in Archives of Toxicology (2017)

  7. No Access

    Article

    Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile

    Multi-pellet formulations are advantageous for the controlled release of drugs over single-unit dosage forms. To understand the diffusion controlled drug release mechanism, the pellet structure and drug releas...

    Shuo Yang, **anzhen Yin, Caifen Wang, Haiyan Li, You He, Tiqiao **ao… in The AAPS Journal (2014)