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Article
Effects of phenamiphos on muscarinic acetylcholine receptor in the brain synaptosome in rats and its mechanism
The studies were performed to investigate the mechanism of phenamiphos affecting muscarinic acetylcholine receptor (M-AchR) of the brain synaptosome in rats. The results showed that phenamiphos inhibited the b...
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Article
A comparative study of the effects of cadmium on microsomal mixed-function oxidase activities between kidney cortex and liver
The effects of cadmium and phenobarbital (PB) administration on the activities of microsomal mixed-function oxidase (MFO) in rat kidney cortex and liver were studied. Five indices, including cytochrome P-450 c...
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Article
Purification of rat liver microsomal glutathione transferase
The rat liver microsomal glutathione transferase was activated by N-ethylmaleimide, solubilized by Triton X-100 and purified by chromatography on hydroxyapatite and CM Sephadex C-50. A 28-fold purification res...
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Article
The effects of cadmium, mercury and lead in vitro on hepatic microsomal mixed function oxidase and lipid peroxidation
In this study, the authors investigated the effect of cadmium, mercury and lead in vitro on hepatic microsomal mixed function oxidase and lipid peroxidation. The results showed that these metals could inhibit ...
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Article
The toxicokinetics of methyl-ISP in rats
The toxicokinetics of methyl-ISP was studied in rats. The logarithm of the pesticide concentration in blood versus time curve following intravenous injection was fitted to two-compartment open model. The toxic...
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Article
Effects of Isophenphos-I on the respiratory function of rat liver mitochondria
The effects of insecticide Isophenphos-I on respiration of rat liver mitochondria were studied. It was found that Isophenphos-I inhibited the respiration of mitochondria both in vivo and in vitro, and reduced ...
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Article
Effects of phosphoramidothiolate pesticides on rat erythrocyte membrane acetylcholinesterase
2-Formoxylisoproianate pheny S-methyl phosphoramidothiolate (FMP), 2-Formoxylisoproianate pheny S-ethyl phosphoramidothiolate (FEP) and 2-Formoxylisoproianate pheny S-propyl phosphoramidothiolate (FPP) are thr...
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Chapter
Effects of 13 Mutagens on Rat Hepatic Microsomal Enzymes
Hepatic microsomal enzymes are the important enzymes involved in the biotransformation of carcinogens. It is known that many drugs, insecticides, and toxic metals are inhibitors of microsomal enzymes and that ...
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Article
Effects of fenvalerate on enzymes of rat liver cell membranes and microsomes
By exploring the effects of fenvalerate on enzymes of rat liver cell membranes and microsomes, it was found that fenvalerate inhibited the activities of liver plasma membrane-bound 5′-Nase and ALP in different...
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Article
On malathion binding to tissue macromolecules in the rat
Five h after administration of35S-malathion (30 μCi) to rats, the amount of total radioactivity and that bound to macromolecules in various tissues were determined. It was found that the amount of bound radioacti...
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Article
Effects of some toxic metals on hepatic microsomal mixed function oxidase system of the rat
In this study the authors studied acute effects of 5 toxic metals (cadmium, mercury, lead, chromium and arsenic) and a lead-zinc ore on microsomal mixed function oxidase system of the male rat. The results sho...
