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Article
HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy
Human immunodeficiency virus type 1 (HIV-1) eradication is prevented by the establishment on infection of cellular HIV-1 reservoirs that are not fully characterized, especially in genital mucosal tissues (the ...
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Article
Open AccessHIV infection and latency induce a unique metabolic signature in human macrophages
Currently, a major barrier to curing HIV infection is the generation of tissue-associated, non-replicating, long-lasting viral reservoirs that are refractory to therapy and can be reactivated upon anti-retrovi...
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Article
Open AccessTunneling nanotubes (TNT) mediate long-range gap junctional communication: Implications for HIV cell to cell spread
Cell-to-cell communication is essen for the development of multicellular systems and is coordinated by soluble factors, exosomes, gap junction (GJ) channels, and the recently described tunneling nanotubes (TNT...
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Article
Open AccessHIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim
While HIV kills most of the cells it infects, a small number of infected cells survive and become latent viral reservoirs, posing a significant barrier to HIV eradication. However, the mechanism by which immun...
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Article
Open AccessHIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS
HIV-associated neurocognitive disorders (HAND) are a major complication in at least half of the infected population despite effective antiretroviral treatment and immune reconstitution. HIV-associated CNS dama...
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Article
Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis
Mutations of the CUL4B ubiquitin ligase gene are causally linked to syndromic X-linked mental retardation (XLMR). However, the pathogenic role of CUL4B mutations in neuronal and developmental defects is not under...
