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Article
Open AccessPlakophilin 4 controls the spatio-temporal activity of RhoA at adherens junctions to promote cortical actin ring formation and tissue tension
Plakophilin 4 (PKP4) is a component of cell–cell junctions that regulates intercellular adhesion and Rho-signaling during cytokinesis with an unknown function during epidermal differentiation. Here we show tha...
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Article
New suture probe canaloplasty combined with suprachoroidal collagen implantation
To present the modified surgery technique of new suture probe canaloplasty with a specially prepared monofilament 4.0 polypropylene suture combined with suprachoroidal drainage (ScD) and collagen sheet implant...
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Article
Open AccessGoing only half the way: cell cycle exit after the G1 restriction point
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Article
Open AccessMild COVID-19 has no detrimental effect on semen quality
As of today, the effect of coronavirus disease 2019 (COVID-19) on male fertility remains unclear. Studies published so far have partly contradictory results, likely due to very small sample sizes and heterogen...
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Article
Open AccessCorrection: Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation
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Article
Open AccessImpact of cement type and abutment height on pull-off force of zirconia reinforced lithium silicate crowns on titanium implant stock abutments: an in vitro study
Pull-off forces of cement-retained zirconia reinforced lithium silicate (ZLS) in implant-supported single crowns on stock titanium abutments with respect to abutment height and implant cement were evaluated an...
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Article
Open AccessIdentification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation
Cancer metastases are the main cause of lethality. The five-year survival rate for patients diagnosed with advanced stage oral cancer is 30%. Hence, the identification of novel therapeutic targets is an urgent...
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Article
Open AccessReconvalescent plasma/camostat mesylate in early SARS-CoV-2 Q-PCR positive high-risk individuals (RES-Q-HR): a structured summary of a study protocol for a randomized controlled trial
Currently, there are no approved treatments for early disease stages of COVID-19 and few strategies to prevent disease progression after infection with SARS-CoV-2. The objective of this study is to evaluate th...
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Article
Open AccessSensitivity of anti-SARS-CoV-2 serological assays in a high-prevalence setting
Evaluation and power of seroprevalence studies depend on the performed serological assays. The aim of this study was to assess four commercial serological tests from EUROIMMUN, DiaSorin, Abbott, and Roche as w...
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Chapter
Risiko und Recht
Die Einführung neuer Technologien im naturwissenschaftlichen-technischen Bereich hat viele begrüßenswerte Neuerungen, aber auch ungeahnte nachteilige Folgen, wie beispielsweise Atomunfälle, hervorgerufen. Kenn...
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Article
Open AccessIntronic tRNAs of mitochondrial origin regulate constitutive and alternative splicing
The presence of nuclear mitochondrial DNA (numtDNA) has been reported within several nuclear genomes. Next to mitochondrial protein-coding genes, numtDNA sequences also encode for mitochondrial tRNA genes. How...
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Article
Degenerative Prozesse aufhalten und verbessern
Bei leichter bis mittelschwerer Demenz kann durch Bewegungsförderung und Training eine Verbesserung der physischen und psychischen Leistungsfähigkeit erzielt werden. Dieser Ansatz kann die medikamentöse und ps...
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Article
Open AccessBaseline levels of dynamic CD4+ T cell adhesion to MAdCAM-1 correlate with clinical response to vedolizumab treatment in ulcerative colitis: a cohort study
While the number of therapeutic options for treating inflammatory bowel diseases (IBD) is increasing, evidence for rational treatment decisions is scarce in many cases. In particular, appropriate biomarkers to...
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Chapter
Rhön-Campus-Konzept: Sektorenübergreifende Gesundheitsversorgung im ländlichen Raum
Das RHÖN-Campus-Konzept bietet seinen Patienten eine sektorenübergreifende Versorgung durch die Zentralisierung verschiedener medizinischer und nichtmedizinischer Leistungsanbieter an einem Ort. Die an der Ver...
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Article
Imitating the cortisol profile improves the immune system
A once-daily, modified-release hydrocortisone medication reduces BMI and improves glucose metabolism compared with the twice- or thrice-daily standard hydrocortisone treatment in patients with adrenal insuffic...
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Chapter and Conference Paper
Quality Improvement of Mobile Apps – Tool-Supported Lightweight Feedback Analyses
Mobile apps have penetrated the market and are used everywhere. The success of apps also depends on user feedback as this enables users to influence other potential customers and provides new opportunities fo...
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Chapter
Risiko und Recht
Die Einführung neuer Technologien im naturwissenschaftlichen- technischen Bereich hat viele begrüßenswerte Neuerungen, aber auch ungeahnte nachteilige Folgen, wie beispielsweise Atomunfälle, hervorgerufen. Ken...
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Chapter
Gender und Recht
Die Frage nach ›Gender und Recht‹ darf nicht missverstanden werden als eine einseitige Betrachtung der ›Frauenrechte‹, auch wenn in der Vergangenheit Frauen wesentlich häufiger diskriminiert wurden als Männer....
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Article
Erratum to: Functional assessments for decision-making regarding return to sports following ACL reconstruction. Part I: development of a new test battery
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Article
Open AccessFunctional assessments for decision-making regarding return to sports following ACL reconstruction. Part I: development of a new test battery
Return to activity remains the most common concern following an injury. To facilitate the decision regarding a patient’s return to sport, we developed a standardized and easy-to-use test battery to enable an o...
