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Article
Open AccessSarcopenic obesity is part of obesity paradox in dementia development: evidence from a population-based cohort study
Sarcopenic obesity, a clinical and functional condition characterized by the coexistence of obesity and sarcopenia, has not been investigated in relation to dementia risk and its onset.
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Article
Open AccessGenomic characterization and immunotherapy for microsatellite instability-high in cholangiocarcinoma
Microsatellite instability-high (MSI-H) is a unique genomic status in many cancers. However, its role in the genomic features and immunotherapy in cholangiocarcinoma (CCA) is unclear. This study aimed to syste...
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Article
Open AccessMigration experiences and reported commercial and non-commercial sexual behaviors among newly diagnosed HIV infections in China: a cross-sectional study
Migration is known to influence human health. China has a high migration rate and a significant number of people who are HIV-positive, but little is known about how these factors intersect in sexual risk behav...
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Article
Open AccessRobotic magnetic navigation-guided pulmonary vein isolation in an atrial fibrillation patient with dextrocardia situs inversus: techniques and potential advantages
Dextrocardia with situs inversus (DSI) is a very rare congenital anomaly. Catheter manipulation and ablation of atrial fibrillation (AF) in patients with this anatomical variant is challenging for the operator...
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Article
Evidence Supporting That C-to-U RNA Editing Is the Major Force That Drives SARS-CoV-2 Evolution
Mutations of DNA organisms are introduced by replication errors. However, SARS-CoV-2, as an RNA virus, is additionally subjected to rampant RNA editing by hosts. Both resources contributed to SARS-CoV-2 mutati...
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Article
Open AccessReal-world systemic sequential therapy with regorafenib for recurrent hepatocellular carcinoma: analysis of 93 cases from a single center
Regorafenib is an oral multikinase inhibitor and became the first second-line systemic treatment for hepatocellular carcinoma (HCC) following the phase III RESORCE trial. This single-center study retrospective...
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Article
Guidelines for the prevention and management of children and adolescents with COVID-19
Children are the future of the world, but their health and future are facing great uncertainty because of the coronavirus disease 2019 (COVID-19) pandemic. In order to improve the management of children with C...
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Article
Comprehensive Relationship Analysis of the Long Noncoding RNAs (lncRNAs) and the Target mRNAs in Response to the Infection of Edwardsiella anguillarum in European eel (Anguilla anguilla) Inoculated with Freund’s Adjuvant
Freund’s complete adjuvant (FCA) and incomplete adjuvant (FIA), generally applied in subunit fishery vaccine, have not been explored on the molecular mechanism of the non-specific immune enhancement. As long n...
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Article
The Sponge Interaction Between Circular RNA and microRNA Serves as a Fast-Evolving Mechanism That Suppresses Non-small Cell Lung Cancer (NSCLC) in Humans
Non-small cell lung cancer (NSCLC) is one of the most lethal cancer types in the world. Currently, the molecular mechanisms and pathways underlying NSCLC oncogenesis are poorly understood. Using multiple Omics...
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Article
Outcrop modeling of flow units and reductant within a sandstone uranium reservoir in the Zhiluo Formation, eastern Ordos Basin: implications for the uranium mineralization mechanism
The spatial distribution of flow units and reductant within a sandstone uranium reservoir is very beneficial for exploring the uranium mineralization mechanism; however, such studies have been almost neglected...
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Article
Open AccessEarly recurrence after cryoballoon versus radiofrequency ablation for paroxysmal atrial fibrillation: mechanism and implication in long-term outcome
Early recurrence (ER) after catheter ablation for atrial fibrillation (AF) has been considered as a common phenomenon but its mechanism and implication in long-term outcome has not been fully elucidated. We ai...
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Article
Differences in D-dimer blood concentration in atrial fibrillation patients with left atrial thrombus or severe left atrial spontaneous echo contrast
Severe left atrial spontaneous echo contrast (SLASEC) is considered the prior stage to thrombosis and a high-risk factor for thrombotic events. Studies have suggested an effect of D-dimer blood concentration o...
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Article
Open AccessLandscape of somatic alterations in large-scale solid tumors from an Asian population
Extending the benefits of tumor molecular profiling for all cancer patients requires a comprehensive analysis of tumor genomes across distinct patient populations worldwide. In this study, we perform deep next...
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Article
Open AccessIdentification of immune infiltration-related genes as prognostic indicators for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has a high degree of malignancy and a poor prognosis. Immune infiltration-related genes have shown good predictive value in the prognosis of many solid tumours. In this study, we...
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Article
Open AccessMethodology and experiences of rapid advice guideline development for children with COVID-19: responding to the COVID-19 outbreak quickly and efficiently
Rapid Advice Guidelines (RAG) provide decision makers with guidance to respond to public health emergencies by develo** evidence-based recommendations in a short period of time with a scientific and standard...
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Article
Relations of Uranium Enrichment and Metal Sulfides within the Shuanglong Uranium Deposit, Southern Ordos Basin
Large quantities of metal sulfides are widely distributed in uranium ores from the Middle Jurassic Zhiluo Formation of the Shuanglong uranium deposit, southern Ordos Basin, providing a convenient condition to ...
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Article
Uranium Metallogeny in Fault-Depression Transition Region: A Case Study of the Tamusu Uranium Deposit in the Bayingobi Basin
Compared to the sandstone-type uranium deposits in the Ordos Basin and the Songliao Basin, the Tamusu uranium deposit in the Bayingobi Basin formed in fault-depression transition region displays distinctive fe...
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Article
Origin of Dispersed Organic Matter within Sandstones and Its Implication for Uranium Mineralization: A Case Study from Dongsheng Uranium Ore Filed in China
Carbonaceous debris (CD), common dispersed organic matter (i.e., DOM), is widely disseminated in sandstones from uranium-bearing strata from the Dongsheng uranium ore field of the northern Ordos Basin. Composi...
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Article
Markers and Genetic Mechanisms of Primary and Epigenetic Oxidation of an Aeolian Depositional System of the Luohandong Formation, Ordos Basin
Uranium exploration breakthrough was extremely rare in an aeolian depositional system. In order to know the complicate characteristics of oxidation associated closely with uranium mineralization in the aeolian...
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Article
Open AccessIntegrated analysis of 1804 samples of six centers to construct and validate a robust immune-related prognostic signature associated with stromal cell abundance in tumor microenvironment for gastric cancer
Stromal cells in tumor microenvironment could promote immune escape through a variety of mechanisms, but there are lacking research in the field of gastric cancer (GC).
