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Article
Open AccessB cells in head and neck squamous cell carcinoma: current opinion and novel therapy
Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumour. Despite advancements in surgery, radiotherapy and chemotherapy, which have improved the prognosis of most patients, a subset of patie...
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Article
Open AccessA novel tyrosine tRNA-derived fragment, tRFTyr, induces oncogenesis and lactate accumulation in LSCC by interacting with LDHA
Transfer (t)RNA-derived small RNA (tsRNA), generated from precursor or mature tRNA, is a new type of small non-coding RNA (sncRNA) that has recently been shown to play a vital role in human cancers. However, i...
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Article
Estimation and compensation of angular misalignment at robot end brush roller-workpiece contact interface via elastic contact force perception
When the non-standard customized brush roller tool is used for robotic grinding of large-scale components, the clam** and positioning error of the brush roller at the end of the robot is extremely easy to ca...
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Article
Open AccessLncRNA TP73‐AS1 promotes nasopharyngeal carcinoma progression through targeting miR-342-3p and M2 polarization via exosomes
Nasopharyngeal carcinoma (NPC) is a deadly cancer, mainly presenting in southeast and east Asia. Long noncoding RNAs (lncRNAs) play essential roles in cancer progression. Exosomes are critical for intercellula...
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Article
Open AccessRBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent
Laryngeal cancer has the highest mortality rate among head and neck tumours. RNA N6-methyladenosine (m6A) is the most plentiful and variable in mammalian mRNA. Yet, the m6A regulatory mechanism underlying the ...
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Article
An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China
Using the Reflux Symptom Index (RSI), this nationwide study aimed to investigate the incidence, diagnostic status, risk factors, and common symptoms of adult laryngopharyngeal reflux disease (LPRD) at otorhino...
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Article
Open AccessLncRNA MSC-AS1 aggravates nasopharyngeal carcinoma progression by targeting miR-524-5p/nuclear receptor subfamily 4 group A member 2 (NR4A2)
Nasopharyngeal carcinoma (NPC) is a subtype of head and neck cancer with dismal prognosis and high relapse rate. The role of long non-coding RNAs (lncRNAs) in NPC has become a research hotspot in recent years....
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Article
Open AccessFADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling
Metabolic abnormality is the major feature of laryngeal squamous cell carcinoma (LSCC), however, the underlying mechanism remain largely elusive. Fatty acid desaturase 1 (FADS1), as the key rate-limiting enzym...
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Article
Assessment of a Truck Localized Air Conditioning System with Thermoelectric Coolers
In vehicles, the power consumption of the traditional air conditioning system used to cool an entire cabin reaches 3–4 kW. In general, there is only one driver in the vehicle, so adjusting the local thermal en...
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Article
Open AccessEffect of DACH1 on proliferation and invasion of laryngeal squamous cell carcinoma
To investigate the effect of DACH1 over-expression on proliferation and invasion of laryngeal squamous cell carcinoma (LSCC).
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Article
Open AccessLong noncoding RNA NEAT1 promotes laryngeal squamous cell cancer through regulating miR-107/CDK6 pathway
Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) plays key role in the progression of some human cancers. However, the role of NEAT1 in human laryngeal squamous cell cancer (LSCC) is still ...
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Article
Open AccessMicroRNA-101 is a potential prognostic indicator of laryngeal squamous cell carcinoma and modulates CDK8
Various microRNAs (miRNAs) negatively modulate genes that are involved in cellular proliferation, differentiation, invasion, and apoptosis. In many types of cancer, the expression profiles of these miRNAs are ...
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Article
Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population
Dongxin Lin and colleagues report a genome-wide association study for laryngeal squamous cell carcinoma (LSCC) in Chinese populations. They identify three loci newly associated with LSCC.
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Open AccessEctopic thyroid papillary carcinoma of nasopharynx associated with adenoid hypertrophy: an unusual presentation
Ectopic thyroid tissue of nasopharynx is an uncommon phenomenon and papillary thyroid carcinoma arising from the tissue is extremely rare. The authors report a rare case of 16-year-old girl with papillary thyr...
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Combined detection of serum exosomal miR-21 and HOTAIR as diagnostic and prognostic biomarkers for laryngeal squamous cell carcinoma
Serum exosomes containing noncoding RNA (ncRNA) play an important role in both physiological and pathological conditions. However, biological function of exosomal ncRNA remains unclear. The aim of the study w...
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Article
MiR-203 is downregulated in laryngeal squamous cell carcinoma and can suppress proliferation and induce apoptosis of tumours
MicroRNAs (miRNAs) have been recognised to regulate cancer development and progression in carcinogenesis as either oncogenes or tumour suppressor genes. However, whether miR-203 plays a crucial role in human l...
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Article
MicroRNA-205 suppresses proliferation and promotes apoptosis in laryngeal squamous cell carcinoma
MicroRNAs were reported to be involved in the modulation of tumor development. The aim of our study was to investigate the effect of miR-205 on proliferation and apoptosis of laryngeal squamous cell carcinoma ...
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Article
Quantitative assessment of the association between GSTM1 null genotype and laryngeal cancer risk
Previous studies investigating the association between glutathione S-transferase M1 (GSTM1) null genotype and laryngeal cancer risk reported controversial results. Thus, a meta-analysis was performed to clarify t...
