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  1. Article

    Open Access

    SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation

    Activation of RIPK1-driven cell death and inflammation play important roles in the progression of nonalcoholic steatohepatitis (NASH). However, the mechanism underlying RIPK1 activation in NASH remains unclear...

    Lingjie Yan, Tao Zhang, Kai Wang, Zezhao Chen, Yuanxin Yang… in Nature Communications (2022)

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  2. No Access

    Article

    Modulating TRADD to restore cellular homeostasis and inhibit apoptosis

    Cell death in human diseases is often a consequence of disrupted cellular homeostasis. If cell death is prevented without restoring cellular homeostasis, it may lead to a persistent dysfunctional and pathologi...

    Daichao Xu, Heng Zhao, Minzhi **, Hong Zhu, Bing Shan, Jiefei Geng… in Nature (2020)