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  1. No Access

    Article

    Yersinia infection induces glucose depletion and AMPK-dependent inhibition of pyroptosis in mice

    Nutritional status and pyroptosis are important for host defence against infections. However, the molecular link that integrates nutrient sensing into pyroptosis during microbial infection is unclear. Here, us...

    Yuanxin Yang, Hongwen Fang, Zhangdan **e, Fandong Ren, Lingjie Yan… in Nature Microbiology (2024)

  2. No Access

    Article

    Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1

    Defects in the prelamin A processing enzyme caused by loss-of-function mutations in the ZMPSTE24 gene are responsible for a spectrum of progeroid disorders characterized by the accumulation of farnesylated prelam...

    Yuanxin Yang, Jian Zhang, Mingming lv, Na Cui, Bing Shan, Qi Sun… in Nature Cell Biology (2024)

  3. Article

    Open Access

    SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation

    Activation of RIPK1-driven cell death and inflammation play important roles in the progression of nonalcoholic steatohepatitis (NASH). However, the mechanism underlying RIPK1 activation in NASH remains unclear...

    Lingjie Yan, Tao Zhang, Kai Wang, Zezhao Chen, Yuanxin Yang… in Nature Communications (2022)

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  4. No Access

    Article

    Modulating TRADD to restore cellular homeostasis and inhibit apoptosis

    Cell death in human diseases is often a consequence of disrupted cellular homeostasis. If cell death is prevented without restoring cellular homeostasis, it may lead to a persistent dysfunctional and pathologi...

    Daichao Xu, Heng Zhao, Minzhi **, Hong Zhu, Bing Shan, Jiefei Geng… in Nature (2020)