90 Result(s)

Article

Architecture design and advanced manufacturing of heart-on-a-chip: scaffolds, stimulation and sensors

Heart-on-a-chip (HoC) has emerged as a highly efficient, cost-effective device for the development of engineered cardiac tissue, facilitating high-throughput testing in drug development and clinical treatment....

Feng Xu, Hang **, Lingling Liu, Yuanyuan Yang… in Microsystems & Nanoengineering (2024)

Article

Digital light processing printed hydrogel scaffolds with adjustable modulus

Hydrogels are extensively explored as biomaterials for tissue scaffolds, and their controlled fabrication has been the subject of wide investigation. However, the tedious mechanical property adjusting process ...

Feng Xu, Hang **, Huiquan Wu, Acan Jiang, Bin Qiu, Lingling Liu… in Scientific Reports (2024)

Article

Correction: Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/ GPX4 expression

Yaya Qiao, Meng Su, Huifang Zhao, Huanle Liu… in Journal of Experimental & Clinical Cancer … (2024)

Article

Rituximab potentially improves clinical outcomes of CAR-T therapy for r/r B-ALL via sensitizing leukemia cells to CAR-T-mediated cytotoxicity and reducing CAR-T exhaustion

Despite chimeric antigen receptor (CAR) T-cell therapy has achieved great advances in recent year, approximately 50% of relapsed/refractory B cell acute lymphoblastic leukemia (r/r B-ALL) patients treated with...

Yangzi Li, Qingya Cui, Sining Liu, Lingling Liu, Megyn Li, Jun Gao… in Cellular Oncology (2024)

Article

Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression

Ferroptosis is a newly identified iron-dependent form of death that is becoming increasingly recognized as a promising avenue for cancer therapy. N6-methyladenosine (m⁶A) is the most abundant reversible methylati...

Yaya Qiao, Meng Su, Huifang Zhao, Huanle Liu… in Journal of Experimental & Clinical Cancer … (2024)

Article

Structurally diverse macrocycle co-crystals for solid-state luminescence modulation

Organic co-crystals offer an opportunity to fabricate organic functional materials. Traditional co-crystals are generally packed following the segregated or mixed stacking mode, leading to the lack of structur...

Bin Li, Lingling Liu, Yuan Wang, Kun Liu, Zhe Zheng, Shougang Sun… in Nature Communications (2024)

Article

JMJD3 regulate H3K27me3 modification via interacting directly with TET1 to affect spermatogonia self-renewal and proliferation

In epigenetic modification, histone modification and DNA methylation coordinate the regulation of spermatogonium. Not only can methylcytosine dioxygenase 1 (TET1) function as a DNA demethylase, converting 5-me...

** Wang, Lingling Liu, Zebin Li, Haoyu Wang, Yuanyuan Ren, Kaisheng Wang… in BMC Genomics (2024)

Article

The association of lymphocyte with hypothyroidism in obstructive sleep apnea

Obstructive sleep apnea (OSA) is a common sleep-breathing disorder. Numerous investigations have found a strong inherent relationship between OSA and hypothyroidism. Studies suggest that lymphocytes may be inv...

**aoyan Fang, Le Wang, Chong Xu, Tuai Xue, Mingchu Zhang… in BMC Pulmonary Medicine (2024)

Article

Generation of a new therapeutic d-peptide that induces the differentiation of acute myeloid leukemia cells through A TLR-2 signaling pathway

Acute myeloid leukemia (AML) is caused by clonal disorders of hematopoietic stem cells. Differentiation therapy is emerging as an important treatment modality for leukemia, given its less toxicity and wider ap...

Fei Yu, Yingshi Chen, Mo Zhou, Lingling Liu, Bingfeng Liu, Jun Liu… in Cell Death Discovery (2024)

Article

Clinical implications of myeloid malignancy‑related somatic mutations in aplastic anemia

Aplastic anemia (AA) is a potentially fatal bone marrow failure syndrome characterized by a paucity of hematopoietic stem cells and progenitor cells with varying degrees of cytopenia and fatty infiltration of ...

Lingling Liu, Danfeng Zhang, Qiuhao Fu, **gdi Wang… in Clinical and Experimental Medicine (2023)

Article

Predicting response to CCRT for esophageal squamous carcinoma by a radiomics-clinical SHAP model

Radical concurrent chemoradiotherapy (CCRT) is frequently used as the first-line treatment for patients with locally advanced esophageal cancer. Unfortunately, some patients respond poorly. To predict response...

Xu Cheng, Yuxin Zhang, Min Zhu, Ruixia Sun, Lingling Liu, Xueling Li in BMC Medical Imaging (2023)

Article

HK3 stimulates immune cell infiltration to promote glioma deterioration

Glioma is the most common and lethal type of brain tumor, and it is characterized by unfavorable prognosis and high recurrence rates. The reprogramming of energy metabolism and an immunosuppressive tumor micro...

Shupeng Li, Ziwei Li, **nyu Wang, Junzhe Zhong, Daohan Yu… in Cancer Cell International (2023)

Article

HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation

Lysine succinylation is one of the major post-translational modifications occurring on histones and is believed to have significant roles in regulating chromatin structure and function. Currently, histone desu...

Jialun Li, Lu Lu, Lingling Liu, Xuelian Ren, Jiwei Chen, **ngzhi Yin… in Cell Discovery (2023)

Article

Asparagine restriction enhances CD8⁺ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response

Robust and effective T cell immune surveillance and cancer immunotherapy require proper allocation of metabolic resources to sustain energetically costly processes, including growth and cytokine production. He...

J. N. Rashida Gnanaprakasam, Bhavana Kushwaha, Lingling Liu… in Nature Metabolism (2023)