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Article
Open AccessThe effect of different flushing and locking techniques on catheter occlusion rates in central venous catheters: protocol for a multicentre, randomized controlled, parallel-group, open-label, superiority clinical trial
Maintaining venous access is of great clinical importance. Running a slow continuous infusion to keep the vein open (KVO) is often used in peripheral intravenous catheters (PIVCs). Previous studies have compar...
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Article
Molecular mechanism of Saikosaponin-d in the treatment of gastric cancer based on network pharmacology and in vitro experimental verification
The study aimed to utilize network pharmacology combined with cell experiments to research the mechanism of action of Saikosaponin-d in the treatment of gastric cancer. Drug target genes were obtained from the...
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Article
Open AccessDevelopment and validation of a simple and practical model for early detection of diabetic macular edema in patients with type 2 diabetes mellitus using easily accessible systemic variables
Diabetic macular edema (DME) is the leading cause of visual impairment in patients with diabetes mellitus (DM). The goal of early detection has not yet achieved due to a lack of fast and convenient methods. Th...
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Article
Toll-like receptor 3 signaling drives enteric glial cells against dextran sulfate sodium-induced colitis in mice
The activation of toll-like receptor 3 (TLR3) has been reported to attenuate astrocytes injury in central nervous system, but its effect on enteric glial cells (EGCs) remains unknown. Here, we confirmed that t...
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Article
Mechanical activation opens a lipid-lined pore in OSCA ion channels
OSCA/TMEM63 channels are the largest known family of mechanosensitive channels1–3, playing critical roles in plant4–7 and mammalian8,9 mechanotransduction. Here we determined 44 cryogenic electron microscopy stru...
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Article
Open AccessThe mechanism of action and experimental verification of Gan-song Yin on renal clear cell carcinoma based on network pharmacology and bioinformatics
Gan-song Yin (GSY) is originated from the scripture “Gan-song Pills”, a medical work of the Ningxia ethnic minorities, and its treatment of kidney diseases has good results. Its method of treating Renal clear ...
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Article
Open AccessMulticenter study of seasonal and regional airborne allergens in Chinese preschoolers with allergic rhinitis
This study is nationwide multicenter epidemiological research, aimed at investigating the distribution changes and seasonal patterns of various airborne allergens among preschool children with allergic rhiniti...
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Article
Open AccessA Cotyledon-based Virus-Induced Gene Silencing (Cotyledon-VIGS) approach to study specialized metabolism in medicinal plants
Virus-induced gene silencing (VIGS) is widely used in plant functional genomics. However, the efficiency of VIGS in young plantlets varies across plant species. Additionally, VIGS is not optimized for many pla...
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Chapter and Conference Paper
Evaluation of Foam Drainage Gas Recovery Technology Test in Xushen Gas Field in Winter
The natural gas supply and demand in Daqing oilfield varies greatly with the seasonal variation. The production in winter is 2–3 times that in summer, and the gas field’s supply protection pressure is huge. Du...
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Article
Open AccessBuilding bridges of excellence: a comprehensive competence framework for nurses in hospice and palliative care—a mixed method study
Hospice and Palliative Care (HPC) is in high demand in China; however, the country is facing the shortage of qualified HPC nurses. A well-suited competence framework is needed to promote HPC human resource dev...
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Article
Open AccessRedox homeostasis dysregulation in noise-induced hearing loss: oxidative stress and antioxidant treatment
Noise exposure is an important cause of acquired hearing loss. Studies have found that noise exposure causes dysregulated redox homeostasis in cochlear tissue, which has been recognized as a signature feature ...
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Article
Open AccessUmbrella strategy with systemic and intraperitoneal chemotherapy versus systemic chemotherapy in patients with advanced gastric cancer: a multicenter, randomized Phase III clinical trial
We have developed a tridirectional regimen combining intraperitoneal, intravenous, and oral chemotherapy as a treatment for patients with advanced gastric cancer and individualized these chemotherapeutics acco...
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Article
Open AccessBioinformatics analysis of immune cell infiltration patterns and potential diagnostic markers in atherosclerosis
This study aimed to investigate efficient diagnostic markers and molecular mechanisms of atherosclerosis and to analyze the role of immune infiltration through bioinformatics analysis. Expression profile datas...
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Article
Open AccessLight regulation of the biosynthesis of phenolics, terpenoids, and alkaloids in plants
Biosynthesis of specialized metabolites (SM), including phenolics, terpenoids, and alkaloids, is stimulated by many environmental factors including light. In recent years, significant progress has been made in...
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Article
A prognostic model incorporating inflammatory cells and cytokines for newly diagnosed multiple myeloma patients
Peripheral blood cell counts and cytokines can be used as predictors of multiple myeloma (MM) patients’ outcomes. 313 newly diagnosed MM patients treated with novel agents were divided into training and valida...
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Article
Open AccessRecognition and cleavage mechanism of intron-containing pre-tRNA by human TSEN endonuclease complex
Removal of introns from transfer RNA precursors (pre-tRNAs) occurs in all living organisms. This is a vital phase in the maturation and functionality of tRNA. Here we present a 3.2 Å-resolution cryo-EM structu...
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Article
Open AccessEpitaxial growth of metal-organic framework nanosheets into single-crystalline orthogonal arrays
Construction of two-dimensional nanosheets into three-dimensional regular structures facilitates the mass transfer and exploits the maximum potential of two-dimensional building blocks in applications such as ...
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Article
Open AccessCorrelation analysis of quantitative MRI measurements of thigh muscles with histopathology in patients with idiopathic inflammatory myopathy
To validate the correlation between histopathological findings and quantitative magnetic resonance imaging (qMRI) fat fraction (FF) and water T2 map** in patients with idiopathic inflammatory myopathy (IIM).
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Article
Thermal and barrier properties of nanocomposites prepared from poly(butylene succinate) reinforced with ZnO-decorated graphene
In this work, the effects of different ZnO-decorated graphene (Graphene-ZnO) proportions on the comprehensive properties of Poly(butylene succinate) (PBS) nanocomposites were investigated. The results show tha...
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Article
Open AccessRCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis
Evidence suggests that calcium release from the endoplasmic reticulum (ER) can be induced to cause calcium overload, which in turn can trigger mitochondrial-dependent apoptosis. Dysregulation of systemic calci...
