33 Result(s)

Article

Emerging trends in the coexistence of primary lung Cancer and hematologic malignancy: a comprehensive analysis of clinicopathological features and genetic abnormalities

The incidence of multiple primary cancers (MPC), especially involving primary lung cancer (PLC) and primary hematologic malignancies (PHM), is rising. This study aims to analyze clinicopathological features, g...

Mengchen Lyu, Lifeng Luo, Ling Zhou, **angran Feng, ** Yang… in Cancer Cell International (2024)

Article

Comprehensive bioinformatics analysis of the solute carrier family and preliminary exploration of SLC25A29 in lung adenocarcinoma

According to the latest epidemiological investigation, lung adenocarcinoma (LUAD) is one of the most fatal cancer among both men and women. Despite continuous advancements in treatment approaches in recent yea...

Pengdou Zheng, Zhenyu Mao, Miao Luo, Ling Zhou, Lingling Wang… in Cancer Cell International (2023)

Article

WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein

Large tumor suppressor kinase 1 (LATS1), one of the predominant components of the Hippo pathway, has been characterized as a key player controlling the proliferation and invasion of cancer cells, including gas...

Jian** Zou, Ling Zhou, Yi Le, Zhi Fang, Min Zhong… in Cell Communication and Signaling (2023)

Article

miR-150-5p in neutrophil-derived extracellular vesicles associated with sepsis-induced cardiomyopathy in septic patients

Early diagnosis and potential therapeutic targets of sepsis-induced cardiomyopathy (SIC) remain challenges clinically. Circulating extracellular vesicles from immune cells carrying crucial injurious mediators,...

Rongzong Ye, Qiuyun Lin, Wenkai **ao, Lixia Mao, Pengfei Zhang… in Cell Death Discovery (2023)

Article

The role of the TGF-β/LIF signaling pathway mediated by SMADs during the cyst formation of Echinococcus in young children

The present study aims to explore the correlation of the transforming growth factor β (TGF-β), drosophila mothers against decapentaplegic protein gene (SMAD) 2/3/4, and leukemia inhibitory factors (LIF) with t...

Shuang-li Qin, Yun Guo, Shui-Xue Li, Ling Zhou… in BMC Molecular and Cell Biology (2022)

Article

The Role of Mitochondrial Quality Control in Cognitive Dysfunction in Diabetes

Type 2 diabetes (T2DM) is a well known risk factor for Alzheimer’s disease. Mitochondria are the center of intracellular energy metabolism and the main source of reactive oxygen species. Mitochondrial dysfunct...

Jian-Sheng Luo, Jia-Qi Ning, Zhuo-Ya Chen, Wen-**g Li… in Neurochemical Research (2022)

Article

Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity

Endometriosis (EMs) occurs in approximately 50% of women with infertility. The main causes of EMs-related infertility are follicle dysplasia and reduced oocyte quality. Iron overload occurs in ovarian follicul...

Zhexin Ni, Yangshuo Li, Di Song, Jie Ding, Shanshan Mei, Shuai Sun… in Cell Death & Disease (2022)

Article

Mesh-like electrospun membrane loaded with atorvastatin facilitates cutaneous wound healing by promoting the paracrine function of mesenchymal stem cells

Functional electrospun membranes are promising dressings for promoting wound healing. However, their microstructure and drug loading capacity need further improvements. It is the first time to design a novel m...

Jieyu **ang, Ling Zhou, Yuanlong **e, Yufan Zhu… in Stem Cell Research & Therapy (2022)

Article

GRP78 blockade overcomes intrinsic resistance to UBA1 inhibitor TAK-243 in glioblastoma

Glioblastoma multiforme (GBM) is the most aggressive malignant primary brain tumor of the central nervous system. Despite continuous progression in treatment options for GBM like surgery, radiotherapy, and che...

Xu Zhang, Runqiu Wu, Cong Tian, Wanzhou Wang, Lingni Zhou… in Cell Death Discovery (2022)

Article

Attenuated succinate accumulation relieves neuronal injury induced by hypoxia in neonatal mice

Hypoxia causes neonatal neuronal damage. However, the underlying mechanism remains unclear. This study aimed to explore the changes in succinate levels and identify the mechanisms underlying their contribution...

Mengdi Zhang, Yao Cheng, Yujie Zhai, Yaru Cui, Wenshen Zhang… in Cell Death Discovery (2022)

Article

Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE

Yinghui Wei, Chunlong Xu, Hu Feng, Kui Xu, Zhifang Li, **g Hu, Ling Zhou… in Cell Discovery (2022)

Article

STAT6 contributes to renal fibrosis by modulating PPARα-mediated tubular fatty acid oxidation

Lipid metabolism, especially fatty acid oxidation (FAO) dysfunction, is a major driver of renal fibrosis; however, the detailed regulatory mechanisms involved remain unclear. In this study, we showed that ther...

Jianzhong Li, You**g Yang, Qianmin Li, Shuhui Wei, Yujia Zhou… in Cell Death & Disease (2022)

Article

TNFAIP3 mutation may be associated with favorable overall survival for patients with T-cell lymphoma

T-cell lymphoma (TCL) is highly aggressive and has a poor prognosis; thus, it is worth exploring biomarkers that may predict clinical outcomes and investigate their potential role in develo** targeted therap...

Cunte Chen, Zheng Chen, Ling Huang, Lingling Zhou, Lihua Zhu… in Cancer Cell International (2021)

Article

Somatic mutations predict prognosis in myelodysplastic syndrome patients with normal karyotypes

**angzong Zeng, Yu Zhang, Ke Zhao… in Signal Transduction and Targeted Therapy (2021)

Article

Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma

Glioblastoma (GBM) is an incurable and highly heterogeneous brain tumor, originating from human neural stem/progenitor cells (hNSCs/hNPCs) years ahead of diagnosis. Despite extensive efforts to characterize hN...

**aofei Wang, Ran Zhou, Yanzhen **ong, Lingling Zhou, **ang Yan… in Cell Research (2021)

Article

RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation

The ongoing 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2 has posed a worldwide pandemic and a major global public health threat. The severity and mortality of COVID-19 are associated with vir...

Yaoxing Wu, Ling Ma, Sihui Cai, Zhen Zhuang… in Signal Transduction and Targeted Therapy (2021)

Article

Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling

Yaoxing Wu, Ling Ma, Zhen Zhuang, Sihui Cai… in Signal Transduction and Targeted Therapy (2020)

Article

APN-mediated phosphorylation of BCKDK promotes hepatocellular carcinoma metastasis and proliferation via the ERK signaling pathway

Hepatocellular carcinoma (HCC) is one of the most prevalent human malignancies worldwide and has high morbidity and mortality. Elucidating the molecular mechanisms underlying HCC recurrence and metastasis is c...

Mengying Zhai, Zixia Yang, Chenrui Zhang, **** Li, **g Jia… in Cell Death & Disease (2020)

Article

GSTM1 and GSTT1 null genotype increase the risk of hepatocellular carcinoma: evidence based on 46 studies

It is well known that hepatocellular carcinoma (HCC) has been one of the most life-threatening diseases all over the world. Plenty of internal and extrinsic factors have been proven to be related to HCC, such ...

Shanli Li, Feng Xue, Yi Zheng, Pengtao Yang, Shuai Lin… in Cancer Cell International (2019)

Article

Anti-tumor effects and mechanism of GA-13315, a novel gibberellin derivative, in human lung adenocarcinoma: an in vitro and in vivo study

To investigate the anti-tumor effects and the mechanism of the compound 13-chlorine-3, 15-dioxy-gibberellic acid methyl ester (GA-13315) in lung adenocarcinoma in vitro and in vivo.

Lin **e, Yajuan Chen, **gbo Chen, Hongbin Zhang… in Cellular & Molecular Biology Letters (2019)