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Article
Open AccessPopulational pan-ethnic screening panel enabled by deep whole genome sequencing
Birth defect is a global threat to the public health systems. Mitigating neonatal anomalies is hampered by elusive molecular mechanisms of pathogenic mutations and poor subsequent translation into preventative...
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Article
Open AccessgcaPDA: a haplotype-resolved diploid assembler
Generating chromosome-scale haplotype resolved assembly is important for functional studies. However, current de novo assemblers are either haploid assemblers that discard allelic information, or diploid assemble...
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Article
Open AccessBrain MRI features of methylmalonic acidemia in children: the relationship between neuropsychological scores and MRI findings
Methylmalonic acidemia (MMA) is a severe, heterogeneous disorder of methylmalonate and cobalamin (cbl; vitamin B12) metabolism with a poor prognosis that can cause brain damage. Identifying the magnetic resona...
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Article
Open AccessBainbridge-ropers syndrome caused by loss-of-function variants in ASXL3: Clinical abnormalities, medical imaging features, and gene variation in infancy of case report
Bainbridge–Ropers syndrome (BRPS) is a recently described developmental disorder caused by de novo truncating mutations in the Additional sex combs-like 3 (ASXL3) gene. Only four cases have been reported in Ch...
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Article
Open AccessSatb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions
The Satb1 genome organizer regulates multiple cellular and developmental processes. It is not yet clear how Satb1 selects different sets of targets throughout the genome. Here we have used live-cell single mol...
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Article
Open AccessGenome assembly of a tropical maize inbred line provides insights into structural variation and crop improvement
Maize is one of the most important crops globally, and it shows remarkable genetic diversity. Knowledge of this diversity could help in crop improvement; however, gold-standard genomes have been elucidated onl...
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Open AccessA new massively parallel nanoball sequencing platform for whole exome research
Whole exome sequencing (WES) has been widely used in human genetics research. BGISEQ-500 is a recently established next-generation sequencing platform. However, the performance of BGISEQ-500 on WES is not well...
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Article
Open AccessA reference-grade wild soybean genome
Efficient crop improvement depends on the application of accurate genetic information contained in diverse germplasm resources. Here we report a reference-grade genome of wild soybean accession W05, with a fin...
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Open AccessAuthor Correction: Liriodendron genome sheds light on angiosperm phylogeny and species–pair differentiation
In the Supplementary Information file originally published with this Letter, the authors mistakenly omitted Supplementary Table 14; this has now been amended.
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Open AccessLiriodendron genome sheds light on angiosperm phylogeny and species–pair differentiation
The genus Liriodendron belongs to the family Magnoliaceae, which resides within the magnoliids, an early diverging lineage of the Mesangiospermae. However, the phylogenetic relationship of magnoliids with eudicot...
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Article
Open AccessPopulation genomics of finless porpoises reveal an incipient cetacean species adapted to freshwater
Cetaceans (whales, dolphins, and porpoises) are a group of mammals adapted to various aquatic habitats, from oceans to freshwater rivers. We report the sequencing, de novo assembly and analysis of a finless po...
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Article
Open AccessGekko japonicus genome reveals evolution of adhesive toe pads and tail regeneration
Reptiles are the most morphologically and physiologically diverse tetrapods, and have undergone 300 million years of adaptive evolution. Within the reptilian tetrapods, geckos possess several interesting featu...
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Erratum: Camelid genomes reveal evolution and adaptation to desert environments
Nature Communications 5:5188; doi: 10.1038/ncomms6188 (2014); Published 21 Oct 2014; Updated 28 Jan 2015 In this Article Junyi Wang is incorrectly listed as one of several equally contributing authors. The cor...
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Open AccessTwo Antarctic penguin genomes reveal insights into their evolutionary history and molecular changes related to the Antarctic environment
Penguins are flightless aquatic birds widely distributed in the Southern Hemisphere. The distinctive morphological and physiological features of penguins allow them to live an aquatic life, and some of them ha...
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Open AccessComparative genomics of Riemerella anatipestifer reveals genetic diversity
Riemerella anatipestifer is one of the most important pathogens of ducks. However, the molecular mechanisms of R. anatipestifer infection are poorly understood. In particular, the lack of genomic information from...
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Open AccessThe Brassica oleracea genome reveals the asymmetrical evolution of polyploid genomes
Polyploidization has provided much genetic variation for plant adaptive evolution, but the mechanisms by which the molecular evolution of polyploid genomes establishes genetic architecture underlying species d...
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Article
Open AccessWhole-genome sequence of a flatfish provides insights into ZW sex chromosome evolution and adaptation to a benthic lifestyle
Songlin Chen and colleagues sequenced the whole genomes of a male (ZZ) and a female (ZW) Chinese half-smooth tongue sole, Cynoglossus semilaevis. Their analysis provides insights into the structure and evolution ...
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Erratum: High genome heterozygosity and endemic genetic recombination in the wheat stripe rust fungus
Nature Communications 4: Article number: 2673 (2013); Published: 23 October 2013; Updated: 29 January 2014. The original version of this Article contained an error in the accession codes section, which specifi...
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Open AccessHigh genome heterozygosity and endemic genetic recombination in the wheat stripe rust fungus
Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most destructive diseases of wheat. Here we report a 110-Mb draft sequence of Pst isolate CY32, obtained using a ‘fosmid-to-fosmid’ ...
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Article
Open AccessThe tiger genome and comparative analysis with lion and snow leopard genomes
Tigers and their close relatives (Panthera) are some of the world’s most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white ...
