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    Metabolic control of DNA methylation in naive pluripotent cells

    Naive epiblast and embryonic stem cells (ESCs) give rise to all cells of adults. Such developmental plasticity is associated with genome hypomethylation. Here, we show that LIF–Stat3 signaling induces genomic ...

    Riccardo M. Betto, Linda Diamante, Valentina Perrera, Matteo Audano… in Nature Genetics (2021)