4 Result(s)
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Lin-Yu Lu
Stem Cells
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Article
Open Access53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice
BRCA1 is critical for DNA double-strand break (DSB) repair by homologous recombination (HR). BRCA1 deficient mice are embryonic lethal. Previous studies have shown that 53BP1 knockout (KO) rescues embryonic le...
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Article
Open AccessNBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis
DNA double-strand breaks (DSBs) pose a serious threat to genomic stability. Paradoxically, hundreds of programed DSBs are generated by SPO11 in meiotic prophase, which are exclusively repaired by homologous re...
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Article
Open AccessBRCA1 and homologous recombination: implications from mouse embryonic development
As an important player in DNA damage response, BRCA1 maintains genomic stability and suppresses tumorigenesis by promoting DNA double-strand break (DSB) repair through homologous recombination (HR). Since the ...
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Article
The role of BRCA1 in DNA damage response
BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic st...
