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Article
Plasmonic refractive index sensitivity of tetrapod gold nanostars: tuning the branch length and protein layer
The refractive index sensitivity of the tetrapod nanostars was studied. The extinction spectra and environmental refractive index sensitivity of the tetrapod gold nanostars with different branch lengths were c...
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Article
BRCA1: a key player at multiple stages of homologous recombination in DNA double-strand break repair
As a key tumor suppressor in several cancers, BRCA1 is required for the maintenance of genomic stability. Extensive studies have revealed multiple functions of BRCA1 that contribute to its role in tumor suppre...
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Article
Open Access53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice
BRCA1 is critical for DNA double-strand break (DSB) repair by homologous recombination (HR). BRCA1 deficient mice are embryonic lethal. Previous studies have shown that 53BP1 knockout (KO) rescues embryonic le...
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Article
Open AccessAberrantly expressed HORMAD1 disrupts nuclear localization of MCM8–MCM9 complex and compromises DNA mismatch repair in cancer cells
HORMAD1 is a meiosis-specific protein that promotes synapsis and recombination of homologous chromosomes in meiotic prophase. Originally identified as a cancer/testis antigen, HORMAD1 is also aberrantly expres...
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Article
Open AccessNBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis
DNA double-strand breaks (DSBs) pose a serious threat to genomic stability. Paradoxically, hundreds of programed DSBs are generated by SPO11 in meiotic prophase, which are exclusively repaired by homologous re...
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Article
Open AccessBRCA1 and homologous recombination: implications from mouse embryonic development
As an important player in DNA damage response, BRCA1 maintains genomic stability and suppresses tumorigenesis by promoting DNA double-strand break (DSB) repair through homologous recombination (HR). Since the ...
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Article
Regulation of the DNA damage response on male meiotic sex chromosomes
During meiotic prophase in males, the sex chromosomes partially synapse to form the XY body, a unique structure that recruits proteins involved in the DNA damage response, which is believed to be important for...
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Article
Chfr and RNF8 synergistically regulate ATM activation
RNF8 is an E3 ligase that functions in the DNA damage response by promoting the ubiquitination of histone proteins at double-strand breaks. Now, analysis of mice with a double knockout of RNF8 and related E3 l...
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Article
The role of BRCA1 in DNA damage response
BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic st...
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Article
Open AccessThe balance of Polo-like kinase 1 in tumorigenesis
Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlap** functions in the cell cycle progression. Plk1 plays a key role...
