77 Result(s)
within
Lin** Shi
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessDevelopment of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylase
DNA base editors enable direct editing of adenine (A), cytosine (C), or guanine (G), but there is no base editor for direct thymine (T) editing currently. Here we develop two deaminase-free glycosylase-based b...
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Article
Open AccessMulti-scale coupled attention for visual object detection
The application of deep neural network has achieved remarkable success in object detection. However, the network structures should be still evolved consistently and tuned finely to acquire better performance. ...
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Article
Open AccessStress increases hepatic release of lipocalin 2 which contributes to anxiety-like behavior in mice
Chronic stress induces anxiety disorders via both neural pathways and circulating factors. Although many studies have elucidated the neural circuits involved in stress-co** behaviors, the origin and regulato...
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Open AccessTreadmill exercise pretreatment ameliorated structural synaptic plasticity impairments of medial prefrontal cortex in vascular dementia rat and improved recognition memory
This study aimed to investigate structural synaptic plasticity in the medial prefrontal cortex of rats under treadmill exercise pretreatment or naive conditions in a vascular dementia model, followed by recogn...
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Open AccessAutophagy regulates the maturation of hematopoietic precursors in the embryo
An understanding of the mechanisms regulating embryonic hematopoietic stem cell (HSC) development would facilitate their regeneration. The aorta-gonad-mesonephros region is the site for HSC production from hem...
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Open AccessLeaf traits of prickly ash and its correlation with ecological and geographical factors of origin
The morphological, physiological, and biochemical characteristics of leaves result from the long-term adaptation of plants to their environment and are closely related to plant growth and development. In this ...
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Open AccessMulti-molecular hyperspectral PRM-SRS microscopy
Lipids play crucial roles in many biological processes. Map** spatial distributions and examining the metabolic dynamics of different lipid subtypes in cells and tissues are critical to better understanding ...
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Open AccessQuercetin-crosslinked chitosan nanoparticles: a potential treatment for allergic rhinitis
Allergic rhinitis (AR) remains a major health problem worldwide. Compared with traditional oral drugs, nasal administration avoids first-pass metabolism and achieve faster and more effective efficacy. In this ...
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Open AccessNew insight in massive cerebral infarction predictions after anterior circulation occlusion
To predict massive cerebral infarction (MCI) occurrence after anterior circulation occlusion (ACO) by cASPECTS-CTA-CS (combined ASPECTS and CTA-CS). Of 185 cerebral infarction patients with the ACO, their coll...
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Open AccessA pan-cancer analysis of anti-proliferative protein family genes for therapeutic targets in cancer
The recently discovered APRO (anti-proliferative protein) family encodes a group of trans-membrane glycoproteins and includes 6 members: TOB1, TOB2, BTG1, BTG2, BTG3 and BTG4. The APRO family is reportedly ass...
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Open AccessDeep learning-based solution for smart contract vulnerabilities detection
This paper aims to explore the application of deep learning in smart contract vulnerabilities detection. Smart contracts are an essential part of blockchain technology and are crucial for develo** decentrali...
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Open AccessA robotic sensory system with high spatiotemporal resolution for texture recognition
Humans can gently slide a finger on the surface of an object and identify it by capturing both static pressure and high-frequency vibrations. Although modern robots integrated with flexible sensors can precise...
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Open AccessIntegrating social and ecological considerations in floodplain relocation and restoration programs
In the United States, most floodplain relocation (or buyout) programs focus on moving homeowners, then deal separately with what happens with the land afterward. These programs typically divide processes for r...
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Open AccessCobalt-catalyzed atroposelective C−H activation/annulation to access N−N axially chiral frameworks
The N−N atropisomer, as an important and intriguing chiral system, was widely present in natural products, pharmaceutical lead compounds, and advanced material skeletons. The anisotropic structural characteris...
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Open AccessEngineered CRISPR-OsCas12f1 and RhCas12f1 with robust activities and expanded target range for genome editing
The type V-F CRISPR-Cas12f system is a strong candidate for therapeutic applications due to the compact size of the Cas12f proteins. In this work, we identify six uncharacterized Cas12f1 proteins with nuclease...
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Open AccessPredicting prostate cancer in men with PSA levels of 4–10 ng/mL: MRI-based radiomics can help junior radiologists improve the diagnostic performance
To develop MRI-based radiomics model for predicting prostate cancer (PCa) in men with prostate-specific antigen (PSA) levels of 4–10 ng/mL, to compare the performance of radiomics model and PI-RADS v2.1, and t...
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Open AccessPredicting the risk of acute kidney injury after hematopoietic stem cell transplantation: development of a new predictive nomogram
The purpose was to predict the risk of acute kidney injury (AKI) within 100 days after hematopoietic stem cell transplantation (HSCT) in patients with hematologic disease by using a new predictive nomogram. Co...
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Glucose-driven TOR–FIE–PRC2 signalling controls plant development
Nutrients and energy have emerged as central modulators of developmental programmes in plants and animals1–3. The evolutionarily conserved target of rapamycin (TOR) kinase is a master integrator of nutrient and e...
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Open AccessModeling the influence of gravity and the mechanical properties of elastin and collagen fibers on alveolar and lung pressure–volume curves
The relationship between pressure (P) and volume (V) in the human lung has been extensively studied. However, the combined effects of gravity and the mechanical properties of elastin and collagen on alveolar a...
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Open AccessA clinical study of peripherally inserted central catheter-related venous thromboembolism in patients with hematological malignancies
This study aimed to explore the risk factors of peripherally inserted central catheter (PICC)-related venous thromboembolism (CRT) in patients with hematological malignancies and the predictive ability of the ...
