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Life Sciences
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Article
Open AccessFertilization regime changes rhizosphere microbial community assembly and interaction in Phoebe bournei plantations
Fertilizer input is one of the effective forest management practices, which improves soil nutrients and microbial community compositions and promotes forest productivity. However, few studies have explored the...
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Metagenomic Next-Generation Sequencing as an Effective Diagnostic Tool for Talaromycosis in HIV-Negative Patients
The diagnosis of Talaromyces marneffei infection in HIV-negative patients remains challenging. There is an urgent need for rapid and convenient methods to diagnose this complicated disease. The aim of this study ...
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Open AccessTranscriptome analysis of Pennisetum americanum × Pennisetum purpureum and Pennisetum americanum leaves in response to high-phosphorus stress
Excessive phosphorus (P) levels can disrupt nutrient balance in plants, adversely affecting growth. The molecular responses of Pennisetum species to high phosphorus stress remain poorly understood. This study exa...
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Reducing Nogo-B Improves Hepatic Fibrosis by Inhibiting BACe1-Mediated Autophagy
Hepatic fibrosis (HF) is a histopathological change in the process of long-term liver injury caused by cytokine secretion and internal environment disturbance, resulting in excessive liver repair and fiber sca...
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Lysosomal cation channel TRPML1 suppression sensitizes acute myeloid leukemia cells to chemotherapeutics by inhibiting autophagy
Despite the implementation of novel therapeutic regimens and extensive research efforts, chemoresistance remains a formidable challenge in the treatment of acute myeloid leukemia (AML). Notably, the involvemen...
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Open AccessIntegration analysis of miRNA-mRNA pairs between two contrasting genotypes reveals the molecular mechanism of jujube (Ziziphus jujuba Mill.) response to high-temperature stress
With global warming, high temperature (HT) has become one of the most common abiotic stresses resulting in significant crop yield losses, especially for jujube (Ziziphus jujuba Mill.), an important temperate econ...
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Open AccessDexmedetomidine improves the circulatory dysfunction of the glymphatic system induced by sevoflurane through the PI3K/AKT/ΔFosB/AQP4 pathway in young mice
Multiple sevoflurane exposures may damage the develo** brain. The neuroprotective function of dexmedetomidine has been widely confirmed in animal experiments and human studies. However, the effect of dexmede...
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Effects of temperature and salinity on indoor preservation of in vitro holdfast of Sargassum fusiforme
Cryopreservation of receptacles or fertilized eggs is the main method for the preservation of indoor germplasm resources for the economic seaweed Sargassum fusiforme. However, none of these methods can achieve lo...
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Open AccessMechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression
Triple-negative breast cancer (TNBC) is recognized as the most aggressive and immunologically infiltrated subtype of breast cancer. A high circulating neutrophil-to-lymphocyte ratio (NLR) is strongly linked to...
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Open AccessEndosome mediated nucleocytoplasmic trafficking and endomembrane allocation is crucial to polyglutamine toxicity
Aggregation of aberrant proteins is a common pathological hallmark in neurodegeneration such as polyglutamine (polyQ) and other repeat-expansion diseases. Here through overexpression of ataxin3 C-terminal poly...
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Changes in root architecture and endogenous hormone levels in alfalfa under phosphorus stress
To explain changes in plant growth, root architecture, and endogenous hormones of different root-type alfalfa to phosphorus (P) stress (non-stressed control, 1.00 mmol·L−1 KH2PO4, versus P stress treatment, 0.01 ...
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hnRNPH1 maintains mitochondrial homeostasis by establishing NRF1/DRP1 retrograde signaling under mitochondrial stress
Mitochondrial homeostasis is coordinated through communication between mitochondria and the nucleus. In response to stress, mitochondria generate retrograde signals to protect against their dysfunction by acti...
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TIPRL, a Potential Double-edge Molecule to be Targeted and Re-targeted Toward Cancer
The target of rapamycin (TOR) proteins exhibits phylogenetic conservation across various species, ranging from yeast to humans, and are classified as members of the phosphatidylinositol kinase (PIK)-related ki...
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Detecting QTL for internode length in rice to improve lodging resistance of high-quality japonica cultivar
Internode length is an important trait to improve the lodging resistance of rice (Oryza sativa), especially for some high-quality japonica cultivars that are highly susceptible to lodging. Yet, there is little in...
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Open AccessGenome-wide identification, molecular evolution and expression analysis of the B-box gene family in mung bean (Vigna radiata L.)
Mung bean (Vigna radiata L.) is an important warm-season grain legume. Adaptation to extreme environmental conditions, supported by evolution, makes mung bean a rich gene pool for stress tolerance traits. The exp...
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Open AccessTranscriptomic analysis reveals the regulatory mechanisms of messenger RNA (mRNA) and long non-coding RNA (lncRNA) in response to waterlogging stress in rye (Secale cereale L.)
Waterlogging stress (WS) negatively impacts crop growth and productivity, making it important to understand crop resistance processes and discover useful WS resistance genes. In this study, rye cultivars and w...
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Open AccessUCHL1 promotes the proliferation of porcine granulosa cells by stabilizing CCNB1
The proliferation of porcine ovarian granulosa cells (GCs) is essential to follicular development and the ubiquitin–proteasome system is necessary for maintaining cell cycle homeostasis. Previous studies found...
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Effect of household pipe materials on formation and chlorine resistance of the early-stage biofilm: various interspecific interactions exhibited by the same microbial biofilm in different pipe materials
Microbial community biofilm exists in the household drinking water system and would pose threat to water quality. This paper explored biofilm formation and chlorination resistance of ten dual-species biofilms ...
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Open AccessAssociation of plasma high-density lipoprotein cholesterol level with risk of stress urinary incontinence in women: a retrospective study
Studies have found that high density lipoprotein cholesterol (HDL-C) levels are linked to a variety of diseases. However, evidence for the relationship between stress urinary incontinence (SUI) and HDL-C remai...
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Open AccessEffects of far-red light on growth, endogenous hormones, antioxidant capacity and quality of Lettuce
This study aimed to explore the effects of various intensities of far-red light on the growth performance, endogenous hormones, antioxidant indices, and overall quality of hydroponically cultivated lettuce. As...
