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Chapter and Conference Paper
Restore Translation Using Equivariant Neural Networks
Invariance to spatial transformations such as translations is a desirable property and a basic design principle for classification neural networks. However, the commonly used convolutional neural networks (CNN...
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Article
Analysis of serum metabolome of laborers exposure to welding fume
Welding fume exposure is inevitable of welding workers and poses a severe hazard to their health since welding is a necessary industrial process. Thus, preclinical diagnostic symptoms of worker exposure are of...
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Article
A trimethine cyanine dye for copper (II) detection based on the transformation between monomers and J-aggregates via G-quadruplex regulation
A trimethine cyanine dye (MTC) was developed for Cu2+ detection. MTC can exhibit different aggregation modes, such as monomers, dimers, H- and J-aggregates. Here, G-quadruplex (G2) with modification of an alkyne ...
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Article
Improve Robustness and Accuracy of Deep Neural Network with L2,∞ Normalization
In this paper, the L2,∞ normalization of the weight matrices is used to enhance the robustness and accuracy of the deep neural network (DNN) with Relu as activation functions. It is shown that the L2,∞ normalizat...
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Article
Achieving optimal adversarial accuracy for adversarial deep learning using Stackelberg games
The purpose of adversarial deep learning is to train robust DNNs against adversarial attacks, and this is one of the major research focuses of deep learning. Game theory has been used to answer some of the bas...
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Article
Open AccessHigh PSQI score is associated with the development of dyskinesia in Parkinson’s disease
Dyskinesia is one of the most disabling motor complications in Parkinson’s Disease (PD). Sleep is crucial to keep neural circuit homeostasis, and PD patients often suffer from sleep disturbance. However, few p...
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Article
Open AccessBenchmarking clustering algorithms on estimating the number of cell types from single-cell RNA-sequencing data
A key task in single-cell RNA-seq (scRNA-seq) data analysis is to accurately detect the number of cell types in the sample, which can be critical for downstream analyses such as cell type identification. Vario...
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Article
Correlation study of parabens in urine, serum, and seminal plasma of adult men in Bei**g, China
The adverse effects of parabens raise concerns about their extensive use as preservatives in consumer products, especially in cosmetics. Until now, their distribution and excretion in humans have attracted lit...
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Article
Lipopolysaccharide-Induced Microglial Neuroinflammation: Attenuation by FK866
Alleviating microglia-mediated neuroinflammation bears great promise to reduce neurodegeneration. Nicotinamide phosphoribosyltransferase (NAMPT) may exert cytokine-like effect in the brain. However, it remains...
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Article
Open AccessSubstantia nigra Smad3 signaling deficiency: relevance to aging and Parkinson’s disease and roles of microglia, proinflammatory factors, and MAPK
Smad3 signaling is indicated to regulate microglia activity. Parkinson’s disease (PD) neurodegeneration is shown to be associated with aging and neuroinflammation. However, it remains unclear about the relatio...
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Protocol
Synthesis and Evaluation of Caged siRNAs with Single cRGD Modification for Photoregulating RNA Interference
We designed and synthesized caged siRNAs with photolabile linker and single cRGD peptide modifications for the photoregulation of gene expression. Photolabile linker and cRGD were inserted at 5′ terminus of si...
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Article
Spectrum of genetic mutations in de novo PUNLMP of the urinary bladder
Our group and others have previously demonstrated the presence of TERT promoter mutations (TERT-mut) in 60–80% of urothelial carcinomas and some of their histologic variants. Five other genes have been frequently...
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Article
Open AccessThioflavin T as an efficient fluorescence sensor for selective recognition of RNA G-quadruplexes
RNA G-quadruplexes (G4s) play important roles in translational regulation, mRNA processing events and gene expression. Therefore, a fluorescent probe that is capable of efficiently recognizing RNA G-quadruplex...
