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Article
Open AccessFirst-line penpulimab (an anti-PD1 antibody) and anlotinib (an angiogenesis inhibitor) with nab-paclitaxel/gemcitabine (PAAG) in metastatic pancreatic cancer: a prospective, multicentre, biomolecular exploratory, phase II trial
Metastatic pancreatic cancer (mPC) has a dismal prognosis. Herein, we conducted a prospective, multicentre, single-arm, phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combinat...
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Article
Open AccessPredictive value of peripheral blood biomarkers in patients with non-small-cell lung cancer responding to anti-PD-1-based treatment
The introduction of the anti-PD-1 antibody has greatly improved the clinical outcomes of patients with non-small cell lung cancer (NSCLC). In this study, we retrospectively analyzed the efficacy of PD-1 antibo...
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Article
Low-Cost Design of Vibration Inspection Equipment for Timber Beam
Experimental modal analysis, a non-destructive test method, may be used to evaluate the mechanical characteristics of wood components. Equipment for data collecting and processing was a crucial element. Commer...
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Article
Electrophilic Halogen Reagents-mediated Halogenation: Synthesis of Halogenated Dihydro-1,3-oxazine Derivatives
Halogenation of N-cinnamylbenzamides and N-[(2H-chromen-3-yl)methyl]benzamides using electrophilic halogen source was reported. Various halogenated dihydro-1,3-oxazine derivatives(45 examples) were synthesized in...
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Article
Open AccessOncogenic activation revealed by FGFR2 genetic alterations in intrahepatic cholangiocarcinomas
Except for gene fusions, FGFR2 genetic alterations in intrahepatic cholangiocarcinomas (ICCs) have received limited attention, leaving patients harboring activating FGFR2 gene mutations with inadequate access ...
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Article
Open AccessMulti-scale investigation of short-range order and dislocation glide in MoNbTi and TaNbTi multi-principal element alloys
Refractory multi-principal element alloys (RMPEAs) are promising materials for high-temperature structural applications. Here, we investigate the role of short-range ordering (SRO) on dislocation glide in the ...
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Article
Open AccessMining of lattice distortion, strength, and intrinsic ductility of refractory high entropy alloys
Severe lattice distortion is a prominent feature of high-entropy alloys (HEAs) considered a reason for many of those alloys’ properties. Nevertheless, accurate characterizations of lattice distortion are still...
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Article
Textural and compositional variation of mica from the Dexing porphyry Cu deposit: constraints on the behavior of halogens in porphyry systems
The Dexing porphyry deposit is the largest porphyry Cu–Mo–Au deposit in South China. Biotite composition can record the physicochemical conditions and evolution history of magmatic-hydrothermal system. Biotite...
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Article
Possible South-Dip** Mesozoic Subduction at Southern Tethys Ocean-Constrained from Global Tectonic Reconstructions and Seismic Tomography
The evolution of the Tethys Ocean involved several episodes of ocean opening (including the Paleo-Tethys and Neo-Tethys) along its southern margin as terranes rifting away from eastern Gondwana. These oceans w...
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Chapter
High-Performance Oversampling ADCs
Modern wireless communications dictate wideband high-resolution ADCs (analog-to-digital converters) with excellent power efficiency. In such context, delta-sigma modulators achieve the goal by utilizing the ov...
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Article
Recent advances and future needs in computational approaches for materials discovery and development
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Article
Automated hierarchical screening of refractory multicomponent alloys with high intrinsic ductility and surface passivation potency
Applications of body-centered-cubic (BCC) refractory multicomponent alloys require their room-temperature ductility and high-temperature surface passivation. Using physics-informed surrogate models and thermod...
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Article
Open AccessCorrection of severe lower extremity deformity with digital hexapod external fixator based on CT data
Our goal was to examine the therapeutic effect of a self-designed digital six-axis external fixator technique for the correction of severe lower extremity deformities.
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Article
Open AccessPrenatal diagnosis and genetic counseling of a uniparental isodisomy of chromosome 8 with no phenotypic abnormalities
Uniparental disomy (UPD) refers to an epigenomic abnormality in which both copies of, or a part of, a homologous pair of chromosomes are inherited from one parent. UPD arises via a number of mechanisms, includ...
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Article
A 124 dB dynamic range sigma-delta modulator applied to non-invasive EEG acquisition using chopper-modulated input-scaling-down technique
With the advancement of brain science in recent years, the non-invasive brain-computer interfaces (BCIs) based on electroencephalogram (EEG) acquisition have been widely adopted in various brain-inspired appli...
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Article
Prognostic aspects of lymphovascular invasion in localized gastric cancer: new insights into the radiomics and deep transfer learning from contrast-enhanced CT imaging
Lymphovascular invasion (LVI) is a factor significantly impacting treatment and outcome of patients with gastric cancer (GC). We aimed to investigate prognostic aspects of a preoperative LVI prediction in GC u...
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Chapter and Conference Paper
A Method for AGV Double-Cycling Scheduling at Automated Container Terminals
Automated container terminal (ACT) plays an important role in the modern logistics and transportation industry. The utilization of automated guided vehicles (AGV) can be effectively promoted by reducing their ...
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Chapter and Conference Paper
Design of Partial Discharge Detection System for High Voltage Electrical Equipment Based on Intelligent Video Detection Algorithm
Whether the high-voltage electrical equipment can operate smoothly has a direct impact on the power supply and power safety. However, in this kind of equipment itself, it is difficult to maintain a stable stat...
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Article
Open AccessSubstitutional adsorptions of chloride at grain boundary sites on hydroxylated alumina surfaces initialize localized corrosion
To understand the chloride (Cl)-induced initiation mechanism of localized corrosion of Aluminum (Al) alloys, we apply density functional theory (DFT) calculations and ab initio molecular dynamics (AIMD) simula...
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Article
Stability of native point defects in α-Al2O3 under aqueous electrochemical conditions
The formation energies of native point defects in crystalline α-Al2O3 were investigated by combining first principles-based methods and theoretical models in a grand canonical framework. For defect formation reac...
