260 Result(s)
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Article
Open AccessSynthetic macrolides overcoming MLSBK-resistant pathogens
Conventional macrolide-lincosamide-streptogramin B-ketolide (MLSBK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...
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CD87-targeted BiTE and CAR-T cells potently inhibit invasive nonfunctional pituitary adenomas
Recently, bispecific T-cell engagers (BiTEs) and chimeric antigen receptor-modified T cells (CAR-Ts) have been shown to have high therapeutic efficacy in hematological tumors. CD87 is highly expressed in solid tu...
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Open AccessEnhanced recombination empowers the detection and map** of Quantitative Trait Loci
Modern plant breeding, such as genomic selection and gene editing, is based on the knowledge of the genetic architecture of desired traits. Quantitative trait loci (QTL) analysis, which combines high throughpu...
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Open AccessPEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3
The peroxisome is a versatile organelle that performs diverse metabolic functions. PEX3, a critical regulator of the peroxisome, participates in various biological processes associated with the peroxisome. Whe...
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Open AccessCharacterization of the DNA accessibility of chloroplast genomes in grasses
Although the chloroplast genome (cpDNA) of higher plants is known to exist as a large protein-DNA complex called ‘plastid nucleoid’, researches on its DNA state and regulatory elements are limited. In this stu...
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Open AccessHaplotype-resolved assembly of a pig genome using single-sperm sequencing
Single gamete cell sequencing together with long-read sequencing can reliably produce chromosome-level phased genomes. In this study, we employed PacBio HiFi and Hi-C sequencing on a male Landrace pig, coupled...
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Author Correction: Designing a synthetic moss genome using GenoDesigner
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Untapped rich microbiota of mangroves of Pakistan: diversity and community compositions
The mangrove ecosystem is the world’s fourth most productive ecosystem in terms of service value and offering rich biological resources. Microorganisms play vital roles in these ecological processes, thus rese...
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Designing a synthetic moss genome using GenoDesigner
The de novo synthesis of genomes has made unprecedented progress and achieved milestones, particularly in bacteria and yeast. However, the process of synthesizing a multicellular plant genome has not progresse...
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Open AccessDistinct properties of putative trophoblast stem cells established from somatic cell nuclear-transferred pig blastocysts
Genetically modified pigs are considered ideal models for studying human diseases and potential sources for xenotransplantation research. However, the somatic cell nuclear transfer (SCNT) technique utilized to...
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Open AccessCEBPB-mediated upregulation of SERPINA1 promotes colorectal cancer progression by enhancing STAT3 signaling
Colorectal cancer (CRC) is a highly malignant carcinoma associated with poor prognosis, and metastasis is one of the most common causes of death in CRC. Serpin Family A Member 1 (SERPINA1) is a serine protease...
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Open AccessLoss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging
Oocyte quality is critical for the mammalian reproduction due to its necessity on fertilization and early development. During aging, the declined oocytes showing with organelle dysfunction and oxidative stress...
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Open AccessGenetic and pharmacological reduction of CDK14 mitigates synucleinopathy
Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-Synuclein (α-Syn) protein. Currently, n...
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A human-specific insertion promotes cell proliferation and migration by enhancing TBC1D8B expression
Human-specific insertions play important roles in human phenotypes and diseases. Here we reported a 446-bp insertion (Insert-446) in intron 11 of the TBC1D8B gene, located on chromosome X, and traced its origin t...
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Genomic data and ecological niche modeling reveal an unusually slow rate of molecular evolution in the Cretaceous Eupteleaceae
Living fossils are evidence of long-term sustained ecological success. However, whether living fossils have little molecular changes remains poorly known, particularly in plants. Here, we have introduced a nov...
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A designer synthetic chromosome fragment functions in moss
Rapid advances in DNA synthesis techniques have enabled the assembly and engineering of viral and microbial genomes, presenting new opportunities for synthetic genomics in multicellular eukaryotic organisms. T...
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Diminishing carryover benefits of earlier spring vegetation growth
Spring vegetation growth can benefit summer growth by increasing foliage area and carbon sequestration potential, or impair it by consuming additional resources needed for sustaining subsequent growth. However...
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Open AccessSingle-cell sequencing reveals increased LAMB3-positive basal keratinocytes and ZNF90-positive fibroblasts in autologous cultured epithelium
Autologous cultured epithelium grafting (ACEG) presents a promising treatment for refractory vitiligo, yet concerns regarding infections and immunological reactions hinder its surgical use due to serum and fee...
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Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism
Glioblastoma is the most lethal primary brain tumor with glioblastoma stem cells (GSCs) atop a cellular hierarchy. GSCs often reside in a perivascular niche, where they receive maintenance cues from endothelia...
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Open AccessUBE2O reduces the effectiveness of interferon-α via degradation of IFIT3 in hepatocellular carcinoma
Interferon (IFN) exerts its effects through interferon-stimulated genes (ISGs), but its efficacy is limited by interferon resistance, which can be caused by the ubiquitination of key proteins. UBE2O was initia...
