422 Result(s)
within
Lian-**ang **ao
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessIn a rat model of bypass DuraGraft ameliorates endothelial dysfunction of arterial grafts
Coronary artery bypass surgery can result in endothelial dysfunction due to ischemia/reperfusion (IR) injury. Previous studies have demonstrated that DuraGraft helps maintain endothelial integrity of saphenous...
-
Article
Open AccessFacile synthesis of elastin nanogels encapsulated decursin for castrated resistance prostate cancer therapy
Nanogels offer hope for precise drug delivery, while addressing drug delivery hurdles is vital for effective prostate cancer (PCa) management. We developed an injectable elastin nanogels (ENG) for efficient dr...
-
Article
Open AccessGlobal critical soil moisture thresholds of plant water stress
During extensive periods without rain, known as dry-downs, decreasing soil moisture (SM) induces plant water stress at the point when it limits evapotranspiration, defining a critical SM threshold (θcrit). Better...
-
Article
Open AccessCircumventing bottlenecks in H2O2 photosynthesis over carbon nitride with iodine redox chemistry and electric field effects
Artificial photosynthesis using carbon nitride (g-C3N4) holds a great promise for sustainable and cost-effective H2O2 production, but the high carrier recombination rate impedes its efficiency. To tackle this cha...
-
Article
Open AccessMultivariate extremes in lakes
Extreme within-lake conditions have the potential to exert detrimental effects on lakes. Here we use satellite observations to investigate how the occurrence of multiple types of extremes, notably algal blooms...
-
Article
Open AccessDynamic characteristics of coal gangue subgrade filler under traffic load based on the hysteretic curves
Traffic cyclic loading is the key factor that leads to the deterioration of the long-term service behavior of subgrade. A series of cyclic triaxial tests was carried out by the large-scale dynamic and static t...
-
Article
Open AccessGIS and cellular automata based slope rainwater movement process model and its application
Rainfall serves as a significant factor contributing to slope stability challenges in mountainous areas, and simulating the process of slope rainwater movement is a crucial approach for analyzing the stability...
-
Article
Open AccessRefraction and topographic risk factors for early myopic regression after small-incision lenticule extraction surgery
We sought to evaluate the topographic risk factors for early myopic regression after small-incision lenticule extraction (SMILE). A retrospective case‒control study was conducted, and individuals who underwent...
-
Article
Open AccessCD74 as a prognostic and M1 macrophage infiltration marker in a comprehensive pan-cancer analysis
CD74 is a type-II transmembrane glycoprotein that has been linked to tumorigenesis. However, this association was based only on phenotypic studies, and, to date, no in-depth mechanistic studies have been condu...
-
Article
Open AccessTargeting pathogenic CD8+ tissue-resident T cells with chimeric antigen receptor therapy in murine autoimmune cholangitis
Primary biliary cholangitis (PBC) is a cholestatic autoimmune liver disease characterized by autoreactive T cell response against intrahepatic small bile ducts. Here, we use Il12b-/-Il2ra-/- mice (DKO mice) as a ...
-
Article
Open AccessAn improved technology for monitoring groundwater flow velocity and direction in fractured rock system based on colloidal particles motion
The colloidal borescope, using colloidal particle motion, is used to monitor the flow velocities and directions of groundwater. It integrates advanced techniques such as microscopy, high-speed photography, and...
-
Article
Open AccessParental emotional warmth and adolescent internet altruism behavior: a moderated mediation model
As a double-edged sword, the Internet is prone to breed cyber violence and bullying on the one hand, on the other hand, it can promote the expansion of altruistic behavior in cyberspace. Exploring the mechanis...
-
Article
Open AccessEffect of radiotherapy on head and neck cancer tissues in patients receiving radiotherapy: a bioinformatics analysis-based study
Radiotherapy is pivotal in treating head and neck cancers including nasopharyngeal, tongue, hypopharyngeal, larynx, maxillary sinus, parotid gland, and oral cancers. It holds the potential for curative effects...
-
Article
Open AccessA distinct class of pan-cancer susceptibility genes revealed by an alternative polyadenylation transcriptome-wide association study
Alternative polyadenylation plays an important role in cancer initiation and progression; however, current transcriptome-wide association studies mostly ignore alternative polyadenylation when identifying puta...
-
Article
Open AccessPredicting long-term time to cardiovascular incidents using myocardial perfusion imaging and deep convolutional neural networks
Myocardial perfusion imaging (MPI) is a clinical tool which can assess the heart's perfusion status, thereby revealing impairments in patients' cardiac function. Within the MPI modality, the acquired three-dim...
-
Article
Open AccessKisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src
Osteoclasts are over-activated as we age, which results in bone loss. Src deficiency in mice leads to severe osteopetrosis due to a functional defect in osteoclasts, indicating that Src function is essential in o...
-
Article
Open AccessChromosome-level genome assembly and annotation of rare and endangered tropical bivalve, Tridacna crocea
Tridacna crocea is an ecologically important marine bivalve inhabiting tropical coral reef waters. High quality and available genomic resources will help us understand the population structure and genetic diversi...
-
Article
Open AccessSystematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3
Progesterone and AdipoQ Receptor 3 (PAQR3) is a member of the AdipoQ receptor. Our previous studies have found that PAQR3 plays a role as a candidate inhibitor in cardiac adenocarcinoma, breast cancer, gastric...
-
Article
Open AccessIsolation and characterization of a pangolin-borne HKU4-related coronavirus that potentially infects human-DPP4-transgenic mice
We recently detected a HKU4-related coronavirus in subgenus Merbecovirus (named pangolin-CoV-HKU4-P251T) from a Malayan pangolin1. Here we report isolation and characterization of pangolin-CoV-HKU4-P251T, the gen...
-
Article
Open AccessCharge-density wave mediated quasi-one-dimensional Kondo lattice in stripe-phase monolayer 1T-NbSe2
The heavy fermion physics is dictated by subtle competing exchange interactions, posing a challenge to their understanding. One-dimensional (1D) Kondo lattice model has attracted special attention in theory, b...
