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  1. Article

    Open Access

    Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes

    DNA methylation variations are prevalent in human obesity but evidence of a causative role in disease pathogenesis is limited. Here, we combine epigenome-wide association and integrative genomics to investigat...

    Liam McAllan, Damir Baranasic, Sergio Villicaña, Scarlett Brown in Nature Communications (2023)

  2. Article

    Open Access

    Chronic intake of high dietary sucrose induces sexually dimorphic metabolic adaptations in mouse liver and adipose tissue

    Almost all effective treatments for non-alcoholic fatty liver disease (NAFLD) involve reduction of adiposity, which suggests the metabolic axis between liver and adipose tissue is essential to NAFLD developmen...

    Erin J. Stephenson, Amanda S. Stayton, Aarti Sethuraman in Nature Communications (2022)

  3. No Access

    Article

    Impact of leucine on energy balance

    Body weight is determined by the balance between energy intake and energy expenditure. When energy intake exceeds energy expenditure, the surplus energy is stored as fat in the adipose tissue, which causes its...

    Liam McAllan, Paul D. Cotter, Helen M. Roche in Journal of Physiology and Biochemistry (2013)