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Article
Fracture mechanism of inclusions in thick plate center under tensile loading
Segregation of solute atoms in the center of thick plates of the tempered steel can cause an inhomogeneous structural transformation and generate micron-sized inclusions, which leads to lamellar tearing of thi...
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Chapter and Conference Paper
Production Characteristics Description and Management Strategy of Water Producing Gas Wells Based on Dynamic Monitoring
In order to solve the problems of fast decline, short life cycle and even rapid water flooding caused by water production in gas wells, by analyzing the differences of reservoir pore structure and gas-water di...
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Article
Two new 22-membered macrolides from Streptomyces sp. HU210
Two new 22-membered macrolide metabolites, phthoramycins B (1) and C (2), were isolated from the fermentation broth of Streptomyces sp. HU210. Their structures were elucidated based on extensive spectroscopic tec...
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Chapter and Conference Paper
Qualification Test Research on Level Transmitter Equipment for Diesel Engine Lubricating Oil System
The number of operating units of nuclear power plants in china has gradually increased, but foreign nuclear equipment suppliers have gradually decreased. Commodity grade item assessment has played a very good ...
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Article
Open AccessComparative analysis of maca (Lepidium meyenii) proteome profiles reveals insights into response mechanisms of herbal plants to high-temperature stress
High-temperature stress (HTS) is one of the main environmental stresses that limit plant growth and crop production in agricultural systems. Maca (Lepidium meyenii) is an important high-altitude herbaceous plant ...
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Article
Two novel milbemycin derivatives from the genetically engineered strain Streptomyces avermitilis AVE-H39
Two novel milbemycin derivatives, 5,27-epoxy-13α-hydroxy milbemycin β11 (1) and 5,27-epoxy-13α-hydroxy-25-ethyl milbemycin β11 (2), were isolated from the genetically engineered strain Streptomyces avermitilis AV...
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Article
Open AccessFunctional characterization of SLC26A3 c.392C>G (p.P131R) mutation in intestinal barrier function using CRISPR/CAS9-created cell models
Congenital chloride diarrhea (CCD) in a newborn is a rare autosomal recessive disorder with life-threatening complications, requiring early diagnostics and treatment to prevent severe dehydration and infant mo...
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Article
Open AccessEpigenetic regulation of NfatC1 transcription and osteoclastogenesis by nicotinamide phosphoribosyl transferase in the pathogenesis of arthritis
Nicotinamide phosphoribosyltransferase (NAMPT) functions in NAD synthesis, apoptosis, and inflammation. Dysregulation of NAMPT has been associated with several inflammatory diseases, including rheumatoid arthr...
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Article
Open AccessIdentification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen
Acetaminophen (APAP) is a commonly used analgesic responsible for more than half of acute liver failure cases. Identification of previously unknown genetic risk factors would provide mechanistic insights and n...
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Article
Open AccessEpigenetic regulation of Runx2 transcription and osteoblast differentiation by nicotinamide phosphoribosyltransferase
Bone degenerative disorders like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis. Although there are studies suggesting that metabolic chan...
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Article
Toughening mechanism of nanocomposite physical hydrogels fabricated by a single gel network with dual crosslinking — The roles of the dual crosslinking points
A facile method to fabricate tough and highly stretchable polyacrylamide (PAM) nanocomposite physical hydrogel (NCP gel) was proposed. The hydrogels are dually crosslinked single network with the PAM grafted v...
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Article
Phase transition temperature controllable poly(acrylamide-co-acrylic acid) nanocomposite physical hydrogels with high strength
Poly(acrylamide-co-acrylic acid) nanocomposite physical (P(AAm-co-AAc)NCP) hydrogels have been prepared through the in situ free radical solution polymerization based on a “single network, dual cross-linkings” st...
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Article
Open AccessIdentification of new biomarkers for Acute Respiratory Distress Syndrome by expression-based genome-wide association study
Accumulated to-date gene microarray data on Acute Respiratory Distress Syndrome (ARDS) in the Gene Expression Omnibus (GEO) represent a rich source for identifying new unsuspected targets and mechanisms of ARD...
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Chapter
Framework of an Ecotourism Early Warning System: What can we Learn for Hainan, China?
Early warning systems (EWSs) are important for risk management. This chapter develops a framework of an ecotourism EWS which includes hazard risk, carrying capacity of service facilities and tourism sites, and...
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Chapter
Economic Valuation of Terrestrial Ecosystem Services: Present and Future Planning Perspectives for Ledong County, Hainan Province, China
Economic valuation of land ecosystem services is a quantitative method for analyzing the ecological impact of land use that provides scientific conclusions for land-use decisions. This paper conducts a land ec...
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Chapter
City in Transition: The Structure of Social Space in Tian** in 2000
Adapting neighborhood-level census data from 2000, this chapter uses factorial ecological analysis method (principal component analysis, PCA) to examine Tian**’s social spatial structure and its formulation m...
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Article
Superconducting pairing symmetry in frustrating t-J model: Electronic Raman absorption
Motivated by the controversy on the pairing symmetry of layered organic superconductors, we study electronic Raman scattering spectra on a frustrating lattice. A two-dimensional t-t′-J-J′ model and the Gutzwiller...
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Article
Open AccessRNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily affects the joints and ultimately leads to their destruction. Growing evidence suggests that synvovial fibroblasts pla...
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Article
Open AccessImpact of genital warts on health related quality of life in men and women in mainland China: a multicenter hospital-based cross-sectional study
Information on the health-related quality of life (HRQoL) of patients with genital warts (GW) in populations in mainland China is still limited. The aim of the study was to use a generic instrument to measure ...
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Article
Open AccessAugmentation of Pulmonary Epithelial Cell IL-8 Expression and Permeability by Pre-B-cell Colony Enhancing Factor
Previous studies in our lab have identified Pre-B-cell colony enhancing factor (PBEF) as a novel biomarker in acute lung injury (ALI). The molecular mechanism of PBEF involvement in the pathogenesis of ALI is ...
