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Article
Open AccessAn epithelial-to-mesenchymal transition induced extracellular vesicle prognostic signature in non-small cell lung cancer
Despite significant therapeutic advances, lung cancer remains the leading cause of cancer-related death worldwide1. Non-small cell lung cancer (NSCLC) patients have a very poor overall five-year survival rate of ...
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Article
Open AccessBNIP3 phosphorylation by JNK1/2 promotes mitophagy via enhancing its stability under hypoxia
Mitophagy is an important metabolic mechanism that modulates mitochondrial quality and quantity by selectively removing damaged or unwanted mitochondria. BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting p...
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Article
Open AccessExploration and characterization of the memcapacitor and memristor properties of Ni–DNA nanowire devices
A 2-μm-long Ni ion-chelated DNA molecule (Ni–DNA) was found for the first time to possess both memcapacitor and memristor properties; this Ni–DNA molecule is known as a dual memory circuit element (memelement)...
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Article
Open AccessmiR-210 Protects Renal Cell Against Hypoxia-induced Apoptosis by Targeting HIF-1 Alpha
The kidney is vulnerable to hypoxia-induced injury. One of the mechanisms underlying this phenomenon is cell apoptosis triggered by hypoxia-inducible factor-1- α (HIF-1α) activation. MicroRNA-210 (miR-210) is ...
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Article
Open AccessMethylene Blue Reduces Acute Cerebral Ischemic Injury via the Induction of Mitophagy
The treatment of stroke is limited by a short therapeutic window and a lack of effective clinical drugs. Methylene blue (MB) has been used in laboratories and clinics since the 1890s. Few studies have reported...
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Article
Open AccessEnhanced Hypoxia-Inducible Factor (HIF)-1α Stability Induced by 5-Hydroxymethyl-2-Furfural (5-HMF) Contributes to Protection against Hypoxia
We first reported the role of 5-hydroxymethyl-2-furfural (5-HMF) against hypoxia. Here, we studied the mechanism by using oxygen-dependent degradation domain (ODD)-Luc mice, which are a useful model to probe t...
