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  1. No Access

    Article

    Isotoosendanin inhibits triple-negative breast cancer metastasis by reducing mitochondrial fission and lamellipodia formation regulated by the Smad2/3-GOT2-MYH9 signaling axis

    Triple-negative breast cancer (TNBC) is incurable and prone to widespread metastasis. Therefore, identification of key targets for TNBC progression is urgently needed. Our previous study revealed that isotoose...

    **g-nan Zhang, Ze Zhang, Zhen-lin Huang, Qian Guo, Ze-qi Wu… in Acta Pharmacologica Sinica (2024)

  2. No Access

    Article

    Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFα-induced vascular endothelial barrier breakdown

    Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high vascularity and frequent metastasis. Tumor-associated abnormal vasculature was reported to accelerate TNBC metastasis. S...

    **-yu Mei, **g-nan Zhang, Wang-ya Jia, Bin Lu, Meng-na Wang… in Acta Pharmacologica Sinica (2022)

  3. No Access

    Protocol

    PGC-1α Overexpression via Local In Vivo Transfection in Mouse Skeletal Muscle

    The overexpression of a specific protein is a common method for investigating the specific biological function of the substance and the mechanism of action. In vivo electrotransfer has been confirmed to be one...

    Dongwook Yeo, Chounghun Kang, Li Li Ji in Nuclear Receptors (2019)

  4. No Access

    Article

    Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway

    Toosendanin (TSN) is the main active compound in Toosendan Fructus and Meliae Cortex, two commonly used traditional Chinese medicines. TSN has been reported to induce hepatotoxicity, but its mechanism remains ...

    Yao **, Zhen-lin Huang, Li Li, Yang Yang, Chang-hong Wang… in Acta Pharmacologica Sinica (2019)

  5. No Access

    Reference Work Entry In depth

    Role of Antioxidant Signaling in Mitochondrial Adaptation to Muscle Contraction

    Generation of reactive oxygen species (ROS) is a ubiquitous biological phenomenon in eukaryotic cell life. It has become clear that ROS at the physiological concentration are not merely damaging agents inflict...

    Li Li Ji in Systems Biology of Free Radicals and Antioxidants (2014)

  6. No Access

    Article

    The difference of glutathione antioxidant system in newly weaned and young mice liver and its involvement in isoline-induced hepatotoxicity

    Cellular glutathione antioxidant system plays important roles in counteracting hepatotoxins-induced oxidative stress injury. The present study was designed to observe the differences of this system in newly we...

    Qing-Ning Liang, Yu-Chen Sheng, ** Jiang, Li-Li Ji, Yu-Ye **a… in Archives of Toxicology (2011)