84 Result(s)
within
Li-** Cao
Science, Humanities and Social Sciences, multidisciplinary
English
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Article
Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F
THE cellular protein p107 and the retinoblastoma protein (pRB) have many features in common. Most strikingly, they contain homologous protein domains that mediate interaction with the oncoproteins of several s...
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Article
The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila
The conserved microRNA miR-34 regulates age-associated events and long-term brain integrity in Drosophila, providing a molecular link between ageing and neurodegeneration.
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Article
Open AccessPerformance of breast cancer screening methods and modality among Chinese women: a report from a society-based breast screening program (SBSP) in Shanghai
To evaluate the screening performance of individual and combined use of clinical breast examination, ultrasonography and mammography in Chinese women, we conducted a biennial breast cancer screening program am...
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Article
Open AccessMap** Spread and Risk of Avian Influenza A (H7N9) in China
The outbreak of human infections with an emerging avian influenza A (H7N9) virus occurred in China in early 2013. It remains unknown what and how the underlying risk factors were involved in the bird-to-human ...
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Article
Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs
Many forms of blindness result from the dysfunction or loss of retinal photoreceptors. Induced pluripotent stem cells (iPSCs) hold great potential for the modelling of these diseases or as potential therapeuti...
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Open AccessMolecular Epidemiology of Human Rhinovirus in Children with Acute Respiratory Diseases in Chongqing, China
Human rhinovirus-C (HRV-C) has been increasingly detected in patients with acute respiratory diseases (ARDs). Prolonged surveillance was performed on children with ARD to investigate the molecular epidemiology...
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Open AccessUtilisation of adsorption and desorption for simultaneously improving protein crystallisation success rate and crystal quality
High-quality protein crystals of suitable size are an important prerequisite for applying X-ray crystallography to determine the 3-dimensional structure of proteins. However, it is often difficult to obtain pr...
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Open AccessUltra-low percolation threshold in ferrite-metal cofired ceramics brings both high permeability and high permittivity
High permeability and high permittivity are hard to be achieved simultaneously, either in single-phased materials or in composite materials, such as ferrite-ferroelectric ceramic composites and ferrite-metal p...
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Open AccessA National Assessment of the Epidemiology of Severe Fever with Thrombocytopenia Syndrome, China
First discovered in rural areas of middle-eastern China in 2009, severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonosis affecting hundreds of cases reported in China each year. U...
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Article
Open AccessStructures, stabilities and electronic properties of defects in monolayer black phosphorus
The structures, stabilities and electronic properties of monolayer black phosphorus (M-BP) with different kinds of defects are investigated within the frame of density-functional theory. All the possible confi...
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Article
Lanosterol reverses protein aggregation in cataracts
Exploring the genetic basis of congenital cataracts in two families identifies a molecule, lanosterol, which prevents intracellular protein aggregation of various cataract-causing mutant crystallins, and which...
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Article
Open AccessDeactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety
The medial prefrontal cortex (mPFC) is implicated in processing sensory-discriminative and affective pain. Nonetheless, the underlying mechanisms are poorly understood. Here we demonstrate a role for excitator...
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Article
Correction: Corrigendum: Lanosterol reverses protein aggregation in cataracts
Nature 523, 607–611 (2015); doi:10.1038/nature14650 In this Letter, author Yong-Bin Yan was incorrectly associated with affiliation number 5 (Department of Ophthalmology, ****g Hospital) instead of affiliatio...
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Article
Open AccessGlass transition of aqueous solutions involving annealing-induced ice recrystallization resolves liquid-liquid transition puzzle of water
Liquid-liquid transition of water is an important concept in condensed-matter physics. Recently, it was claimed to have been confirmed in aqueous solutions based on annealing-induced upshift of glass-liquid tr...
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Article
Open AccessHydrogen Impurity Defects in Rutile TiO2
Hydrogen-related defects play crucial roles in determining physical properties of their host oxides. In this work, we report our systematic experimental and theoretical (based on density functional theory) stu...
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Open AccessThe Roles of MicroRNA-122 Overexpression in Inhibiting Proliferation and Invasion and Stimulating Apoptosis of Human Cholangiocarcinoma Cells
Our study investigated whether microRNA-122 (miR-122) played important roles in the proliferation, invasion and apoptosis of human cholangiocarcinoma (CC) cells. QBC939 and RBE cells lines were chosen and divi...
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Article
Open AccessRisk Distribution of Human Infections with Avian Influenza H7N9 and H5N1 virus in China
It has been documented that the epidemiological characteristics of human infections with H7N9 differ significantly between H5N1. However, potential factors that may explain the different spatial distributions ...
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Open AccessThe Dendrobium catenatum Lindl. genome sequence provides insights into polysaccharide synthase, floral development and adaptive evolution
Orchids make up about 10% of all seed plant species, have great economical value and are of specific scientific interest because of their renowned flowers and ecological adaptations. Here, we report the first ...
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Open AccessNovel loci and pathways significantly associated with longevity
Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated ...
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Open AccessGreen self-assembly of zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites with high cytotoxicity and immune organs targeting
Inorganic nanomedicines in the fight against cancer have progressed rapidly during recent years, with the synergistic advantages of multifunctional nanosystems compared to single component. Herein, a drug-comb...
