18 Result(s)

Article

Develo** prediction models for short-term mortality after surgery for colorectal cancer using a Danish national quality assurance database

The majority of colorectal cancer surgeries are performed electively, and treatment is often decided at the multidisciplinary team conference. Although the average 30-day mortality rate is low, there is substa...

Karoline B. Bräuner, Andreas W. Rosen… in International Journal of Colorectal Disease (2022)

Article

Early relapse post autologous transplant is a stronger predictor of survival compared with pretreatment patient factors in the novel agent era: analysis of the Singapore Multiple Myeloma Working Group

The clinical outcome of multiple myeloma is heterogeneous. Both the depth of response to induction and transplant as well as early relapse within a year are correlated with survival, but it is unclear which fa...

S Y Ong, S de Mel, Y X Chen, M G Ooi, S Surendran, A Lin… in Bone Marrow Transplantation (2016)

Chapter

The Health Burden of Obesity

Obesity constitutes a significant and rapidly increasing public health challenge, and is associated with increased risks for many of the most serious diseases and conditions affecting modern populations, inclu...

Eugenia A. Lin MD, Gillian M. Barlow PhD… in The Clinician’s Guide to the Treatment of … (2015)

Article

The FoxO–BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress

Normal cells possess adaptive mechanisms to couple energy availability with cell growth (cell size increase) and survival, and imbalances are associated with major diseases such as cancer. Inactivation of crit...

A Lin, J Yao, L Zhuang, D Wang, J Han, E W-F Lam, B Gan in Oncogene (2014)

Article

Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells

Chondrosarcoma is the second most common sarcoma in bone malignancy and is characterized by a high metastatic potential. Angiogenesis is essential for the cancer metastasis. Endothelin-1 (ET-1) has been implic...

M-H Wu, C-Y Huang, J-A Lin, S-W Wang, C-Y Peng, H-C Cheng, C-H Tang in Oncogene (2014)

Article

Why Physicians Favor Use of Percutaneous Coronary Intervention to Medical Therapy: A Focus Group Study

Percutaneous coronary intervention (PCI) is performed in many patients with stable coronary artery disease, despite evidence of little clinical benefit over optimal medical therapy.

Grace A. Lin MD, R. Adams Dudley MD, MBA… in Journal of General Internal Medicine (2008)

Article

Resident Perceptions of the Impact of Work Hour Limitations

Mandatory work hour limitations for residents began in July 2003. There has been little evaluation of the impact of the new limitations on Internal Medicine residency training.

Grace A. Lin MD, David C. Beck MD, PhD… in Journal of General Internal Medicine (2007)

Article

Wiring the cell signaling circuitry by the NF-κB and JNK1 crosstalk and its applications in human diseases

Integration of the cell signaling circuitry determines the ultimate response of a cell to extracellular stimuli. The transcription factor nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase JNK1 a...

J Liu, A Lin in Oncogene (2007)

Article

Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells

Redox modification of thiol/disulfide interchange in proteins by selenium could lead to protein unfolding. When this occurs in the endoplasmic reticulum (ER), a process known as unfolded protein response (UPR)...

K Zu, T Bihani, A Lin, Y-M Park, K Mori, C Ip in Oncogene (2006)

Article

Regulation of the antibody class switch to IgA

Yi-Chaung A. Lin, Penny Shockett, Janet Stavnezer in Immunologic Research (1991)