45,737 Result(s)

Article

The Role of Histone H2B Acetylation Modification in Aluminum-Induced Cognitive Dysfunction

Aluminum (Al) is a low toxic trace element that can accumulate in the nervous system and induce cognitive disorders characterized by reduced learning and memory ability. Neuroepigenetic effects are structural ...

Jie Gao, Wei Liu, **g Pei, **g Li, Ni** Hao… in Biological Trace Element Research (2024)

Article

The Relationship Between Heavy Metals and Missed Abortion: Using Mediation of Serum Hormones

Accumulating evidence suggests that heavy metal exposure may have adverse effects on the fetal development. Furthermore, disruption of serum hormone homeostasis can result in the adverse pregnancy outcomes. Th...

Haixia Liu, Zhilan Li, Li’ao **e, Guangzhuang **g… in Biological Trace Element Research (2024)

Article

Comprehensive Insights into the Health Effects of Selenium Exposure and Supplementation Among the Chinese Community Middle-Aged and Elderly: a Combined Retrospective Cohort Study and Intervention Study

Selenium (Se) is an essential trace element for maintaining human health, for example, plays a crucial role in preventing aging-related diseases. However, most studies on the health effects of Se among the com...

Chen Li, **angwen Peng, Jiayang Zheng, Kexin Shi… in Biological Trace Element Research (2024)

Article

Effects of miR-204-5p and Target Gene EphB2 on Cognitive Impairment Induced by Aluminum Exposure in Rats

Aluminum is a common environmental neurotoxin. Aluminum ions can cross the blood–brain barrier and accumulate in different brain regions, damage brain tissue, and cause cognitive impairment, but the molecular ...

Wei Liu, Jie Gao, Ni** Hao, **g Li, **g Pei… in Biological Trace Element Research (2024)

Article

The key role of myostatin b in somatic growth in fishes derived from distant hybridization

The basic mechanism of heterosis has not been systematically and completely characterized. In previous studies, we obtained three economically important fishes that exhibit rapid growth, WR (WCC ♀ × RCC ♂), WR...

Qingfeng Liu, Lujiao Duan, Bei Li, Xuanyi Zhang, Fanglei Liu… in Science China Life Sciences (2024)

Article

Non-B-form DNA is associated with centromere stability in newly-formed polyploid wheat

Non-B-form DNA differs from the classic B-DNA double helix structure and plays a crucial regulatory role in replication and transcription. However, the role of non-B-form DNA in centromeres, especially in poly...

Congyang Yi, Qian Liu, Yuhong Huang, Chang Liu, **anrui Guo… in Science China Life Sciences (2024)

Article

VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates

α-Synuclein (α-Syn) aggregation is closely associated with Parkinson’s disease neuropathology. Physiologically, α-Syn promotes synaptic vesicle (SV) clustering and soluble N-ethylmaleimide-sensitive factor attach...

Chuchu Wang, Kai Zhang, Bin Cai, Jillian E. Haller… in Nature Cell Biology (2024)

Article

CYTOR-NFAT1 feedback loop regulates epithelial-mesenchymal transition of retinal pigment epithelial cells

Epithelial mesenchymal transition (EMT) occurring in retinal pigment epithelial cells (RPE) is a crucial mechanism that contributes to the development of age-related macular degeneration (AMD), a pivotal facto...

Rong Zhang, Lin Wang, Yang Li, Yan Liu, Kui Dong, Ya**g Pei, Junmei Zhao… in Human Cell (2024)

Article

DNMT1 driven by mouse amniotic fluid mesenchymal stem cell exosomes improved corneal cryoinjury via inducing microRNA-33 promoter DNA hypermethylation modification in corneal epithelium cells

Severe corneal cryoinjury can cause permanent corneal swelling and bullous keratopathy, one of the main reason for loss of sight. Mouse amniotic fluid mesenchymal stem cells (mAF-MSCs) can repair corneal damag...

Weiqi Xu, **nfeng Fei, Zeyu Cui, Dikang Pan, Yan Liu, Te Liu in Human Cell (2024)

Article

Engineering biomimetic nanosystem targeting multiple tumor radioresistance hallmarks for enhanced radiotherapy

Tumor cells establish a robust self-defense system characterized by hypoxia, antioxidant overexpression, DNA damage repair, and so forth to resist radiotherapy. Targeting one of these features is insufficient ...

Shuxiang Wang, Hongmei Cao, Cui-Cui Zhao, Qian Wang… in Science China Life Sciences (2024)

Article

Overexpressing Bcl-2 enhances murine chimeric antigen receptor T cell therapy against solid tumor

Chimeric antigen receptor T (CART) cell therapy has demonstrated promising potential in the treatment of hematologic malignancies. However, its application to solid tumors is limited due to the restrictive nat...

**aoyan Wang, Guodong Liu, **anggang Shi, Yuxing Wang, Bo Jiang, Wei Liu… in Human Cell (2024)

Article

Liquiritin inhibits TGF-β1-induced epithelial mesenchymal transition and extracellular matrix deposition in human renal proximal tubular epithelial cells by suppressing the MAPK signaling

Excessive extracellular matrix (ECM) deposition leads to renal fibrosis, a typical hallmark of chronic kidney disease. Liquiritin is a flavonoid extracted from the rhizome part of Glycyrrhiza glabra and has an...

Zhen Chen, Yi jue Liu, Bo Yu, Wei Li, Mengli Zhang… in Molecular & Cellular Toxicology (2024)

Article

Reducing Nogo-B Improves Hepatic Fibrosis by Inhibiting BACe1-Mediated Autophagy

Hepatic fibrosis (HF) is a histopathological change in the process of long-term liver injury caused by cytokine secretion and internal environment disturbance, resulting in excessive liver repair and fiber sca...

LiLi Gao, YingJie Zhuang, ZhengYi Liu in Tissue Engineering and Regenerative Medicine (2024)

Article

FEZF2 inhibits the growth of triple-negative breast cancer cells through EZH2/PD-L1 and enhances anti-tumor immunity in vivo

Triple-negative breast cancer (TNBC) is characterized by high aggressiveness, heterogeneity, and poor prognosis. Programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors, a crucial type of i...

Wenyu Li, Hu Liu, Wenjuan Li, Qiujun Zhang, Qianyu Zhang… in Molecular & Cellular Toxicology (2024)

Article

Hi-TOM 2.0: an improved platform for high-throughput mutation detection

Tingting Sun, Qing Liu, ** Chen, Fengyue Hu, Kejian Wang in Science China Life Sciences (2024)

Article

Temporal and spatial dynamics of rotifer communities in the Pearl River Delta (China) with emphasis on DNA metabarcoding versus morphology to assess rotifer diversity

Rotifers are essential invertebrates in freshwater ecosystems. Rotifer community structure reflects the environmental changes. To assess the diversity of rotifers in the Pearl River Delta, we investigated the ...

Qing Wang, Wenbo Wang, Lu Liu, Shiqin Tang, Yufeng Yang in Hydrobiologia (2024)

Article

Two sex pheromone receptors for sexual communication in the American cockroach

Volatile sex pheromones are vital for sexual communication between males and females. Females of the American cockroach, Periplaneta americana, produce and emit two sex pheromone components, periplanone-A (PA) an...

Na Li, Renke Dong, Huanchao Zeng, Yan Zhang, Run Huang… in Science China Life Sciences (2024)