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Author Correction: In vivo tracking of functionally tagged Rad51 unveils a robust strategy of homology search
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Publisher Correction: In vivo tracking of functionally tagged Rad51 unveils a robust strategy of homology search
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In vivo tracking of functionally tagged Rad51 unveils a robust strategy of homology search
Homologous recombination (HR) is a major pathway to repair DNA double-strand breaks (DSB). HR uses an undamaged homologous DNA sequence as a template for copying the missing information, which requires identif...
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Open AccessDiverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers
The relationships between chromosomal compartmentalization, chromatin state and function are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon cancer cells, we distinguish thr...
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Open AccessAuthor Correction: The 4D Nucleome Data Portal as a resource for searching and visualizing curated nucleomics data
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Open AccessMCM complexes are barriers that restrict cohesin-mediated loop extrusion
Eukaryotic genomes are compacted into loops and topologically associating domains (TADs)1–3, which contribute to transcription, recombination and genomic stability4,5. Cohesin extrudes DNA into loops that are tho...
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Open AccessThe 4D Nucleome Data Portal as a resource for searching and visualizing curated nucleomics data
The 4D Nucleome (4DN) Network aims to elucidate the complex structure and organization of chromosomes in the nucleus and the impact of their disruption in disease biology. We present the 4DN Data Portal ( ...
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Open AccessSystematic evaluation of chromosome conformation capture assays
Chromosome conformation capture (3C) assays are used to map chromatin interactions genome-wide. Chromatin interaction maps provide insights into the spatial organization of chromosomes and the mechanisms by wh...
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DNA-loop-extruding SMC complexes can traverse one another in vivo
Chromosome organization mediated by structural maintenance of chromosomes (SMC) complexes is vital in many organisms. SMC complexes act as motors that extrude DNA loops, but it remains unclear what happens whe...
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Kee** chromatin in the loop(s)
Eukaryotic chromosomes are huge DNA polymers organized in space and time. Chromatin loo** compacts these polymers, helps genome organization by the formation of enhancer–promoter and other interactions, and ...
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Open AccessMolecular basis of CTCF binding polarity in genome folding
Current models propose that boundaries of mammalian topologically associating domains (TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by cohesin. While the orientation of...
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Open AccessThe genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos
Genome organization involves cis and trans chromosomal interactions, both implicated in gene regulation, development, and disease. Here, we focus on trans interactions in Drosophila, where homologous chromosomes ...
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Open AccessHighly structured homolog pairing reflects functional organization of the Drosophila genome
Trans-homolog interactions have been studied extensively in Drosophila, where homologs are paired in somatic cells and transvection is prevalent. Nevertheless, the detailed structure of pairing and its functional...
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Publisher Correction: Heterochromatin drives compartmentalization of inverted and conventional nuclei
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Heterochromatin drives compartmentalization of inverted and conventional nuclei
The nucleus of mammalian cells displays a distinct spatial segregation of active euchromatic and inactive heterochromatic regions of the genome1,2. In conventional nuclei, microscopy shows that euchromatin is loc...
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Open AccessHiGlass: web-based visual exploration and analysis of genome interaction maps
We present HiGlass, an open source visualization tool built on web technologies that provides a rich interface for rapid, multiplex, and multiscale navigation of 2D genomic maps alongside 1D genomic tracks, al...
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Correction: Corrigendum: The 4D nucleome project
Nature 549, 219–226 (2017); doi:10.1038/nature23884 This Perspective should have contained the following Acknowledgements section: ‘We would like to thank the National Institutes of Health (NIH) Common Fund, t...
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The 4D nucleome project
The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the...
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Single-nucleus Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition
Using a single-nucleus Hi-C protocol, the authors find that spatial organization of chromatin during oocyte-to-zygote transition differs between paternal and maternal nuclei within a single-cell zygote.
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Super-resolution imaging reveals distinct chromatin folding for different epigenetic states
Using super-resolution imaging to directly observe the three-dimensional organization of Drosophila chromatin at a scale spanning sizes from individual genes to entire gene regulatory domains, the authors find th...
