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Article
Open AccessC57Bl/6N mice have an attenuated lung inflammatory response to dsRNA compared to C57Bl/6J and BALB/c mice
Lower respiratory infections caused by ssRNA viruses are a major health burden globally. Translational mouse models are a valuable tool for medical research, including research on respiratory viral infections....
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Article
Open AccessDirect effects of mast cell proteases, tryptase and chymase, on bronchial epithelial integrity proteins and anti-viral responses
Mast cells (MCs) are known to contribute to both acute and chronic inflammation. Bronchial epithelial cells are the first line of defence against pathogens and a deficient anti-viral response has been suggeste...
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Article
Open AccessHuman host defense peptide LL-37 facilitates double-stranded RNA pro-inflammatory signaling through up-regulation of TLR3 expression in vascular smooth muscle cells
The importance of human host defense peptide LL-37 in vascular innate immunity is not understood. Here, we assess the impact of LL-37 on double-stranded RNA (dsRNA) signaling in human vascular smooth muscle ce...
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Article
Open AccessRhinovirus-induced IFNβ expression is NFκB-dependent and regulated by the macrophage microenvironment
Macrophages play an important role in asthma pathogenesis both in the inflammatory and resolution phase of the disease. Macrophages can acquire different polarisation states dependent on their microenvironment...
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Article
Open AccessInterferon-β deficiency at asthma exacerbation promotes MLKL mediated necroptosis
Defective production of antiviral interferon (IFN)-β is thought to contribute to rhinovirus-induced asthma exacerbations. These exacerbations are associated with elevated lung levels of lactate dehydrogenase (...
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Article
Open AccessIL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation
Viral-induced asthma exacerbations, which exhibit both Th1-type neutrophilia and Th2-type inflammation, associate with secretion of Interleukin (IL)-1β. IL-1β induces neutrophilic inflammation. It may also inc...
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Article
Open AccessAzithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients
Rhinovirus infection is a major cause of chronic obstructive pulmonary disease (COPD) exacerbations and may contribute to the development into severe stages of COPD. The macrolide antibiotic azithromycin may e...
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Article
Open AccessIncreased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation
Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA chall...
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Article
Open AccessRhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33
Bronchial smooth muscle cells (BSMCs) from severe asthmatics have been shown to overexpress the Th2-driving and asthma-associated cytokine IL-33. However, little is known regarding factors involved in BSMC pro...
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Article
Primary lysis of eosinophils as a major mode of activation of eosinophils in human diseased tissues
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Article
Open AccessResolution of cell-mediated airways diseases
"Inflammation resolution" has of late become a topical research area. Activation of resolution phase mechanisms, involving select post-transcriptional regulons, transcription factors, 'autacoids', and cell phe...
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Article
Open AccessEarly phase resolution of mucosal eosinophilic inflammation in allergic rhinitis
It is widely assumed that apoptosis of eosinophils is a central component of resolution of allergic airway disease. However, this has not been demonstrated in human allergic airways in vivo. Based on animal in...
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Article
Open AccessRemodeling of extra-bronchial lung vasculature following allergic airway inflammation
We previously observed that allergen-exposed mice exhibit remodeling of large bronchial-associated blood vessels. The aim of the study was to examine whether vascular remodeling occurs also in vessels where a ...
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Article
Open AccessAntagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation
Mast cell-derived prostaglandin D2 (PGD2), may contribute to eosinophilic inflammation and mucus production in allergic asthma. Chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2), a high ...
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Article
Open AccessNeutrophil cannibalism – a back up when the macrophage clearance system is insufficient
During a lipopolysaccharide-induced lung inflammation, a massive accumulation of neutrophils occurs, which is normally cleared by macrophage phagocytosis following neutrophil apoptosis. However, in cases of ex...
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Article
Open AccessAnti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation
Fas receptor-mediated eosinophil apoptosis is currently forwarded as a mechanism resolving asthma-like inflammation. This view is based on observations in vitro and in airway lumen with unknown translatability to...
