7 Result(s)
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Article
Open AccessStructure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry
Since 2019, SARS-CoV-2 has evolved rapidly and gained resistance to multiple therapeutics targeting the virus. Development of host-directed antivirals offers broad-spectrum intervention against different varia...
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Article
Open AccessStructure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir
The persistent pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants accentuates the great demand for develo** effective ther...
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Article
Open AccessEbola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association
Ebola virus (EBOV), one of the deadliest viruses, is the cause of fatal Ebola virus disease (EVD). The underlying mechanism of viral replication and EBOV-related hemorrhage is not fully understood. Here, we sh...
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Article
Open AccessIdentification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) urgently needs an effective cure. 3CL protease (3CLpro) is a highly conserved cys...
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Article
Open AccessInhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
The SARS-CoV-2 pandemic has triggered global efforts to develop therapeutics. The main protease of SARS-CoV-2 (Mpro), critical for viral replication, is a key target for therapeutic development. An organoselenium...
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Article
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of coronavirus disease 2019 (COVID-19)1–4
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Article
Open AccessThe metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment
Chronic infection caused by the hepatitis B virus (HBV), is strongly associated with hepatitis, fatty liver and hepatocellular carcinoma. To investigate the underlying mechanisms, we characterize the metabolic...
