30 Result(s)

Article

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

Respiratory disease caused by coronavirus infection remains a global health crisis. Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available, their efficacy on emerging coronavi...

**ong **e, Qiaoshuai Lan, **yi Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry

Since 2019, SARS-CoV-2 has evolved rapidly and gained resistance to multiple therapeutics targeting the virus. Development of host-directed antivirals offers broad-spectrum intervention against different varia...

Haofeng Wang, Qi Yang, **aoce Liu, Zili Xu, Maolin Shao, Dongxu Li… in Nature Communications (2023)

Article

Correction: Discovery of novel non-peptidic and non-covalent small-molecule 3CL^pro inhibitors as potential candidate for COVID-19 treatment

Zhidong Jiang, Bo Feng, Yumin Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir

The persistent pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants accentuates the great demand for develo** effective ther...

**angrui Jiang, Haixia Su, Weijuan Shang, Feng Zhou, Yan Zhang… in Nature Communications (2023)

Article

A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir

During the ongoing pandemic, providing treatment consisting of effective, low-cost oral antiviral drugs at an early stage of SARS-CoV-2 infection has been a priority for controlling COVID-19. Although Paxlovid...

Yumin Zhang, Yuan Sun, Yuanchao **e… in Signal Transduction and Targeted Therapy (2023)

Article

Discovery of novel non-peptidic and non-covalent small-molecule 3CL^pro inhibitors as potential candidate for COVID-19 treatment

Zhidong Jiang, Bo Feng, Yumin Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

In the original publication the author’s name ‘Dimitri Lavillete’ is published incorrectly. The correct author name should be spelt as ‘Dimitri Lavillette’ is provided in this correction.

Rui **ong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang… in Protein & Cell (2022)

Article

Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332

Yao Zhao, Chao Fang, Qi Zhang, Ruxue Zhang, **angbo Zhao, Yinkai Duan… in Protein & Cell (2022)

Article

Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association

Ebola virus (EBOV), one of the deadliest viruses, is the cause of fatal Ebola virus disease (EVD). The underlying mechanism of viral replication and EBOV-related hemorrhage is not fully understood. Here, we sh...

Lin Zhu, Ting Gao, Yi Huang, **g **, Di Wang, Leike Zhang… in Nature Communications (2022)

Article

Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model

Ruxue Zhang, Yumin Zhang, Wei Zheng… in Signal Transduction and Targeted Therapy (2022)

Article

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

Safe, effective, and economical vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed to achieve adequate herd immunity and end the pandemic. We constructed a novel SARS-CoV-...

Yiru Long, Jianhua Sun, Tian-Zhang Song, Tingting Liu, Feng Tang… in Cell Discovery (2022)

Article

Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2

Yuanchao **e, Wanchao Yin, Yumin Zhang, Weijuan Shang, Zhen Wang… in Cell Research (2021)

Article

High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors

A new coronavirus (SARS-CoV-2) has been identified as the etiologic agent for the COVID-19 outbreak. Currently, effective treatment options remain very limited for this disease; therefore, there is an urgent n...

Yao Zhao, **aoyu Du, Yinkai Duan, **aoyan Pan, Yifang Sun, Tian You… in Protein & Cell (2021)

Article

Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease

The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) urgently needs an effective cure. 3CL protease (3CL^pro) is a highly conserved cys...

Haixia Su, Sheng Yao, Wenfeng Zhao, Yumin Zhang, Jia Liu… in Nature Communications (2021)

Article

Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 M^pro

Zhengyuan Wang, Yao Zhao, Qingxing Wang… in Signal Transduction and Targeted Therapy (2021)

Article

Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives

The SARS-CoV-2 pandemic has triggered global efforts to develop therapeutics. The main protease of SARS-CoV-2 (M^pro), critical for viral replication, is a key target for therapeutic development. An organoselenium...

Kangsa Amporndanai, **aoli Meng, Weijuan Shang, Zhenmig **… in Nature Communications (2021)

Article

Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin

The COVID-19 pandemic caused by nonstop infections of SARS-CoV-2 has continued to ravage many countries worldwide. Here we report that suramin, a 100-year-old drug, is a potent inhibitor of the SARS-CoV-2 RNA-...

Wanchao Yin, **aodong Luan, Zhihai Li, Ziwei Zhou… in Nature Structural & Molecular Biology (2021)

Article

Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

In the original publication there are few errors in Figure 1. The correct Figure 1 is provided in this correction

Rui **ong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang… in Protein & Cell (2021)

Article

Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro

The recent outbreak of novel coronavirus pneumonia (COVID-19) caused by a new coronavirus has posed a great threat to public health. Identifying safe and effective antivirals is of urgent demand to cure the hu...

Leike Zhang, Jia Liu, Ruiyuan Cao, Mingyue Xu, Yan Wu, Weijuan Shang… in Virologica Sinica (2020)