10 Result(s)
within
Lee Murphy
Human Genetics
-
Article
Open AccessEpigenetic scores derived in saliva are associated with gestational age at birth
Epigenetic scores (EpiScores), reflecting DNA methylation (DNAm)-based surrogates for complex traits, have been developed for multiple circulating proteins. EpiScores for pro-inflammatory proteins, such as C-r...
-
Article
Open AccessIntegration of datasets for individual prediction of DNA methylation-based biomarkers
Epigenetic scores (EpiScores) can provide biomarkers of lifestyle and disease risk. Projecting new datasets onto a reference panel is challenging due to separation of technical and biological variation with ar...
-
Article
Open AccessRefining epigenetic prediction of chronological and biological age
Epigenetic clocks can track both chronological age (cAge) and biological age (bAge). The latter is typically defined by physiological biomarkers and risk of adverse health outcomes, including all-cause mortali...
-
Article
Open AccessDNA methylation age of blood predicts all-cause mortality in later life
DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on DNA methylation levels. It is not yet known whether DNA methylation age captures aspects of biolo...
-
Article
Open AccessPedigree and genoty** quality analyses of over 10,000 DNA samples from the Generation Scotland: Scottish Family Health Study
Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based biobank of 24,000 participants with rich phenotype and DNA available for genetic research. This paper describes the laboratory resu...
-
Article
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
Hugh Markus, Peter Donnelly and colleagues report a genome-wide association study for ischemic stroke. They identify a SNP in HDAC9, a histone deacetylase gene, that is associated with large vessel ischemic strok...
-
Article
Open AccessGenomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens
Pseudomonas fluorescens are common soil bacteria that can improve plant health through nutrient cycling, pathogen antagonism and induction of plant defenses. The genome sequences of strains SBW25 and Pf0-1 were d...
-
Article
Open AccessThe complete genome, comparative and functional analysis of Stenotrophomonas maltophiliareveals an organism heavily shielded by drug resistance determinants
Stenotrophomonas maltophilia is a nosocomial opportunistic pathogen of the Xanthomonadaceae. The organism has been isolated from both clinical and soil environments in addition to the sputum of cystic fibrosis pa...
-
Article
Comparative genomic analysis of three Leishmania species that cause diverse human disease
Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these...
-
Protocol
Sequencing Bacterial Artificial Chromosomes
Over the last 7 years, there have been enormous changes to the methods being used to sequence DNA. These changes include the increased use of fluorescent dyes to label DNA in the sequencing reaction, improveme...
