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Article
Open AccessIntegrating Diversity, Equity, and Inclusion into Preclinical, Clinical, and Public Health Mathematical Models
Mathematical modelling applied to preclinical, clinical, and public health research is critical for our understanding of a multitude of biological principles. Biology is fundamentally heterogeneous, and mathem...
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Chapter
Fractal-Based Morphometrics of Glioblastoma
Morphometrics have been able to distinguish important features of glioblastoma from magnetic resonance imaging (MRI). Using morphometrics computed on segmentations of various imaging abnormalities, we show tha...
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Article
Open AccessIntegrated molecular and multiparametric MRI map** of high-grade glioma identifies regional biologic signatures
Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis...
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Article
Open AccessShape matters: morphological metrics of glioblastoma imaging abnormalities as biomarkers of prognosis
Lacunarity, a quantitative morphological measure of how shapes fill space, and fractal dimension, a morphological measure of the complexity of pixel arrangement, have shown relationships with outcome across a ...
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Article
A Mechanistic Investigation into Ischemia-Driven Distal Recurrence of Glioblastoma
Glioblastoma (GBM) is the most aggressive primary brain tumor with a short median survival. Tumor recurrence is a clinical expectation of this disease and usually occurs along the resection cavity wall. Howeve...
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Article
Learning Equations from Biological Data with Limited Time Samples
Equation learning methods present a promising tool to aid scientists in the modeling process for biological data. Previous equation learning studies have demonstrated that these methods can infer models from r...
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Article
Open AccessSex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences.
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Article
Speed Switch in Glioblastoma Growth Rate due to Enhanced Hypoxia-Induced Migration
We analyze the wave speed of the Proliferation Invasion Hypoxia Necrosis Angiogenesis (PIHNA) model that was previously created and applied to simulate the growth and spread of glioblastoma (GBM), a particular...
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Chapter and Conference Paper
Sex Differences in Predicting Fluid Intelligence of Adolescent Brain from T1-Weighted MRIs
Fluid intelligence (Gf) has been defined as the ability to reason and solve previously unseen problems. Links to Gf have been found in magnetic resonance imaging (MRI) sequences such as functional MRI and diff...
