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Article
Open AccessAuthor Correction: Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models
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Article
Open AccessSenotherapeutic peptide treatment reduces biological age and senescence burden in human skin models
Cellular senescence is known to play a role in age-related skin function deterioration which potentially influences longevity. Here, a two-step phenotypic screening was performed to identify senotherapeutic pe...
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Article
Open AccessHighly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging
DNA methylation (DNAm) age constitutes a powerful tool to assess the molecular age and overall health status of biological samples. Recently, it has been shown that tissue-specific DNAm age predictors may pres...
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Article
Open AccessIncreased oxidative phosphorylation in response to acute and chronic DNA damage
Accumulation of DNA damage is intricately linked to aging, aging-related diseases and progeroid syndromes such as Cockayne syndrome (CS). Free radicals from endogenous oxidative energy metabolism can damage DN...
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Article
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion
Matthew Meyerson and colleagues report the whole-genome sequencing of primary colorectal tumors and matched adjacent non-tumor tissue from nine individuals with colorectal cancer. They identify a recurrent VTI1A-...
