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  1. No Access

    Article

    Evidence for 28 genetic disorders discovered by combining healthcare and research data

    De novo mutations in protein-coding genes are a well-established cause of developmental disorders1. However, genes known to be associated with developmental disorders account for only a minority of the observed e...

    Joanna Kaplanis, Kaitlin E. Samocha, Laurens Wiel, Zhancheng Zhang… in Nature (2020)

  2. Article

    Open Access

    Heterozygous missense variants of LMX1A lead to nonsyndromic hearing impairment and vestibular dysfunction

    Unraveling the causes and pathomechanisms of progressive disorders is essential for the development of therapeutic strategies. Here, we identified heterozygous pathogenic missense variants of LMX1A in two familie...

    Mieke Wesdorp, Pia A. M. de Koning Gans, Margit Schraders, Jaap Oostrik… in Human Genetics (2018)

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  3. No Access

    Chapter and Conference Paper

    KeCo: Kernel-Based Online Co-agreement Algorithm

    We propose a kernel-based online semi-supervised algorithm that is applicable for large scale learning tasks. In particular, we use a multi-view learning framework and a co-agreement strategy to take into acco...

    Laurens Wiel, Tom Heskes, Evgeni Levin in Discovery Science (2015)