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Chapter
Regulation of Neurotransmitter Release by K+ Channels
K+ channels play potent roles in the process of neurotransmitter release by influencing the action potential waveform and modulating neuronal excitability and release probability. These diverse effects of K+ chan...
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Chapter
Microcircuits of the Dorsal Cochlear Nucleus
The dorsal cochlear nucleus (DCN) integrates excitatory input from auditory and nonauditory sources. Auditory signals are conveyed to the deep layer by the auditory nerve and by excitatory interneurons in the ...
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Article
Regulation of interneuron excitability by gap junction coupling with principal cells
Electrical coupling in the brain usually occurs between inhibitory neurons that are anatomically and functionally similar. Here the authors show that the excitability of inhibitory interneurons in the dorsal c...
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Article
Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport
The authors report that rat brain glutamatergic synaptic vesicles express monovalent cation/H+ exchangers that convert the Δψ of the proton electrochemical gradient into Δψ. They find that this K+/H+ exchange sti...
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Article
KCNQ5 channels control resting properties and release probability of a synapse
Huang and Trussell show that resting potential of the calyx of Held synapse is controlled by KCNQ5 potassium channels. Unlike most KCNQ channels, which activate only on depolarization, these presynaptic channe...
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Article
Slow glycinergic transmission mediated by transmitter pooling
Fast-acting neurotransmitters are usually cleared quickly from synaptic regions, making the time course of synaptic responses independent of active sites. The authors describe an exception to this rule at glyc...
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Chapter
The Role of Potassium Channels in the Regulation of Neurotransmitter Release
Neurotransmitter release is critically dependent on the duration of the presynaptic action potential. A variety of K+ channels play key roles in determining spike width. Moreover, K+ channels control how readily ...
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Article
Cell-specific, spike timing–dependent plasticities in the dorsal cochlear nucleus
In the dorsal cochlear nucleus, long-term synaptic plasticity can be induced at the parallel fiber inputs that synapse onto both fusiform principal neurons and cartwheel feedforward inhibitory interneurons. He...
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Article
Transmission at the hair cell synapse
In cochlear hair cells, each transmitter release site communicates information about sound frequency and intensity. Now the first direct electrophysiological recordings from the structures postsynaptic to thes...