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  1. Article

    Open Access

    Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity

    Cytosine base editors (CBEs) enable efficient, programmable reversion of T•A to C•G point mutations in the human genome. Recently, cytosine base editors with rAPOBEC1 were reported to induce unguided cytosine ...

    Yi Yu, Thomas C. Leete, David A. Born, Lauren Young… in Nature Communications (2020)

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