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Article
Open AccessPreventing erosion of X-chromosome inactivation in human embryonic stem cells
X-chromosome inactivation is a paradigm of epigenetic transcriptional regulation. Female human embryonic stem cells (hESCs) often undergo erosion of X-inactivation upon prolonged culture. Here, we investigate ...
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Article
Open AccessMolecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels
Cancer metastasis is the process by which primary cancer cells invade through the lymphatic or blood vessels to distant sites. The molecular mechanisms by which cancer cells spread either through the lymphatic...
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Article
Open AccessPolycystic ovary syndrome phenotype does not have impact on oocyte morphology
The primary objective of the present study of women participating in an ICSI program was to determine whether the morphologic quality of oocytes was related to the polycystic ovary syndrome (PCOS) phenotype.
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Article
Open AccessClinical relevance of blood-based ctDNA analysis: mutation detection and beyond
Cell-free DNA (cfDNA) derived from tumours is present in the plasma of cancer patients. The majority of currently available studies on the use of this circulating tumour DNA (ctDNA) deal with the detection of ...
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Article
Open AccessDevelopmental potential of aneuploid human embryos cultured beyond implantation
Aneuploidy, the presence of an abnormal number of chromosomes, is a major cause of early pregnancy loss in humans. Yet, the developmental consequences of specific aneuploidies remain unexplored. Here, we deter...
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Article
Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells
Single-cell technologies have contributed to unravelling tumour heterogeneity, now considered a hallmark of cancer and one of the main causes of tumour resistance to cancer therapies. Liquid biopsy (LB), defin...
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Article
Vitamin D deficiency versus non-accidental trauma: comment on “Rickets or abuse? A histologic comparison of rickets and child abuse-related fractures”
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Article
Open AccessRhoB modifies estrogen responses in breast cancer cells by influencing expression of the estrogen receptor
RhoB has been reported to exert positive and negative effects on cancer pathophysiology but an understanding of its role in breast cancer remains incomplete. Analysis of data from the Oncomine database showed ...
