14 Result(s)

Article

Early prediction of acute necrotizing pancreatitis by artificial intelligence: a prospective cohort-analysis of 2387 cases

Pancreatic necrosis is a consistent prognostic factor in acute pancreatitis (AP). However, the clinical scores currently in use are either too complicated or require data that are unavailable on admission or l...

Szabolcs Kiss, József Pintér, Roland Molontay, Marcell Nagy… in Scientific Reports (2022)

Article

Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome

Clinical observations and preclinical studies both suggest that Down syndrome (DS) may be associated with significant metabolic and bioenergetic alterations. However, the relevant scientific literature has not...

Laszlo Pecze, Elisa B. Randi, Csaba Szabo in Molecular Medicine (2020)

Article

Using data on snus use in Sweden to compare different modelling approaches to estimate the population health impact of introducing a smoke-free tobacco product

We have developed an approach for modelling the health impact of introducing new smoke-free tobacco products. We wished to compare its estimates with those of alternative approaches, when applied to snus, used...

Smilja Djurdjevic, Laszlo Pecze, Rolf Weitkunat, Frank Luedicke… in BMC Public Health (2019)

Article

Albumin evokes Ca²⁺-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin

In proteinuric nephropathies of chronic kidney disease, the epithelial cells of the nephron including the collecting duct are exposed to high concentrations of luminal albumin. Albumin is taken up from collect...

Mustafa Nazıroğlu, Bilal Çiğ, Yener Yazğan, Gerburg K. Schwaerzer… in Scientific Reports (2019)

Article

ADP-Ribose and oxidative stress activate TRPM8 channel in prostate cancer and kidney cells

Activation of TRPM8 channel through oxidative stress may induce Ca²⁺ and pro-apoptotic signals in prostate cancer and kidney cells. The aim of this study was to evaluate activation of TRPM8 can increase apoptosis...

Ercan Baş, Mustafa Nazıroğlu, László Pecze in Scientific Reports (2019)

Article

Absence of calretinin protein expression in malignant mesotheliomas from asbestos-exposed NF2^+/− mice and mouse mesothelioma cell lines from various mouse strains

Calretinin is the most widespread positive marker for the immunohistochemical identification of malignant mesothelioma (MM) and was proposed to serve as a blood-based biomarker. Functionally, evidence has accu...

Walter Blum, Thomas Henzi, Hugues-Etienne Châtel-Soulet, Laszlo Pecze… in Biomarker Research (2018)

Article

Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter

The calcium-binding protein calretinin (gene name: CALB2) is currently considered as the most sensitive and specific marker for the diagnosis of malignant mesothelioma (MM). MM is a very aggressive tumor strongly...

Walter Blum, László Pecze, Janine Wörthmüller Rodriguez, Martine Steinauer… in BMC Cancer (2018)

Article

Putative cancer stem cells may be the key target to inhibit cancer cell repopulation between the intervals of chemoradiation in murine mesothelioma

Cancer cell repopulation during chemotherapy or radiotherapy is a major factor limiting the efficacy of treatment. Cancer stem cells (CSC) may play critical roles during this process. We aim to demonstrate the...

Licun Wu, Walter Blum, Chang-Qi Zhu, Zhihong Yun, Laszlo Pecze… in BMC Cancer (2018)

Article

Erratum to: Establishment of immortalized murine mesothelial cells and a novel mesothelioma cell line

Walter Blum, László Pecze… in In Vitro Cellular & Developmental Biology … (2017)

Article

Overexpression or absence of calretinin in mouse primary mesothelial cells inversely affects proliferation and cell migration

The Ca²⁺-binding protein calretinin is currently used as a positive marker for identifying epithelioid malignant mesothelioma (MM) and reactive mesothelium, but calretinin’s likely role in mesotheliomagenesis rem...

Walter Blum, László Pecze, Emanuela Felley-Bosco, Beat Schwaller in Respiratory Research (2015)

Article

Establishment of immortalized murine mesothelial cells and a novel mesothelioma cell line

Mesothelial cells are susceptible to asbestos fiber-induced cytotoxicity and on longer time scales to transformation; the resulting mesothelioma is a highly aggressive neoplasm that is considered as incurable ...

Walter Blum, László Pecze… in In Vitro Cellular & Developmental Biology … (2015)

Article

Besides neuro-imaging, the Thy1-YFP mouse could serve for visualizing experimental tumours, inflammation and wound-healing

The B6.Cg-Tg(Thy1-YFP)16Jrs/J transgenic mouse strain, widely used to study neuronal development and regeneration, expresses the yellow fluorescent protein (YFP) in the peripheral nerves and the central nervou...

Katalin Jósvay, Zoltán Winter, Róbert L. Katona, László Pecze… in Scientific Reports (2014)

Article

Divalent Heavy Metal Cations Block the TRPV1 Ca²⁺ Channel

Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel involved in pain sensation and in a wide range of non-pain-related physiological and pathological conditions. The aim of the p...

László Pecze, Zoltán Winter, Katalin Jósvay… in Biological Trace Element Research (2013)