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Article
Open AccessVideo support for prehospital stroke consultation: implications for system design and clinical implementation from prehospital simulations
Video consultations between hospital-based neurologists and Emergency Medical Services (EMS) have potential to increase precision of decisions regarding stroke patient assessment, management and transport. In ...
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Article
Open AccessDo patients with large vessel occlusion ischemic stroke harboring prestroke disability benefit from thrombectomy?
Evidence of endovascular treatment (EVT) for acute large vessel occlusion (LVO) ischemic stroke in patients harboring substantial prestroke disability is lacking due to their exclusion from randomized trials. ...
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Article
Open AccessCirculating neurofilament light in ischemic stroke: temporal profile and outcome prediction
Neurofilament light chain (NfL) is a marker of neuroaxonal damage. We aimed to study associations between serum NfL (sNfL) concentrations at different time points after ischemic stroke and outcomes.
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Article
Open AccessTransient increase in CSF GAP-43 concentration after ischemic stroke
Cerebrospinal fluid (CSF) biomarkers reflect ongoing processes in the brain. Growth-associated protein 43 (GAP-43) is highly upregulated in brain tissue shortly after experimental ischemia suggesting the CSF G...
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Article
Open AccessCerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia
Frontotemporal dementia (FTD) is recognised as a clinically and morphologically heterogeneous group of interrelated neurodegenerative conditions. One of the subtypes within this disease spectrum is the behavio...
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Article
Open AccessEffects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid
Alzheimer's disease (AD) and cerebrovascular disease (CVD) including chronic small vessel disease of the brain (SVD) are the most frequent causes of dementia. AD is associated with metabolism of amyloid precur...
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Article
Open AccessAmyloid and tau cerebrospinal fluid biomarkers in HIV infection
Because of the emerging intersections of HIV infection and Alzheimer's disease, we examined cerebrospinal fluid (CSF) biomarkers related of amyloid and tau metabolism in HIV-infected patients.
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Article
Serum S-100B protein levels in patients with herpes simplex encephalitis and tick-borne encephalitis — A marker of CNS damage during the initial stage of disease
This study was mainly aimed at the comparative analysis of serum S-100B protein in patients with herpes simplex encephalitis (HSE) and tick-borne encephalitis (TBE). S-100B protein is an established biochemica...
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Article
Explorative investigation of biomarkers of brain damage and coagulation system activation in clinical stroke differentiation
A simple and accurate method of differentiating ischemic stroke and intracerebral hemorrhage (ICH) is potentially useful to facilitate acute therapeutic management. Blood measurements of biomarkers of brain da...
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Article
Defining and Evaluating HIV-Related Neurodegenerative Disease and Its Treatment Targets: A Combinatorial Approach to Use of Cerebrospinal Fluid Molecular Biomarkers
There are a number of reasons that the accomplishments of clinical trials related to HIV-related neurodegenerative disease (HRND) and the AIDS dementia complex (ADC) have had such limited impact on clinical pr...
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Article
Open AccessNormalisation of cerebrospinal fluid biomarkers parallels improvement of neurological symptoms following HAART in HIV dementia – case report
Since the introduction of HAART the incidence of HIV dementia has declined and HAART seems to improve neurocognitive function in patients with HIV dementia. Currently, HIV dementia develops mainly in patients ...
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Article
Open AccessCerebrospinal fluid signs of neuronal damage after antiretroviral treatment interruption in HIV-1 infection
The neurofilament is a major structural component of myelinated axons. Increased cerebrospinal fluid (CSF) concentrations of the light chain of the neurofilament protein (NFL) can serve as a sensitive indicato...
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Article
Marked increase of β-amyloid(1–42) and amyloid precursor protein in ventricular cerebrospinal fluid after severe traumatic brain injury
Severe traumatic brain injury (TBI) may result in widespread damage to axons, termed diffuse axonal injury. Alzheimer’s disease (AD) is characterised by synaptic and axonal degeneration together with senile pl...
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Article
Incidence of CSF abnormalities in siblings of multiple sclerosis patients and unrelated controls
We found that 19% (9/47) of healthy siblings of patients with clinically definite multiple sclerosis had an intrathecal immunological reaction with two or more 2 CSF-enriched oligoclonal bands (OCBs), in cont...
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Article
Difference in pathogenesis between herpes simplex virus type 1 encephalitis and tick-borne encephalitis demonstrated by means of cerebrospinal fluid markers of glial and neuronal destruction
We determined the extent of neuronal and glial cell destruction in 13 patients with herpes simplex type 1 (HSV-1) encephalitis, 15 patients with tick-borne encephalitis (TBE), and 20 noninfectious controls by...
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Chapter and Conference Paper
A Multi-Nozzle Piezoelectric Microdispenser for Improving the Dynamic Volumetric Range of Droplets
A micromachined silicon flow-through microdispenser has been developed and evaluated. The reported device, designed for large volume droplet ejection, was constructed in silicon by DRIE etching and wafer bondi...
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Chapter and Conference Paper
High-Throughput SNP Scoring in a Disposable Microfabricated CD Device
Our approach is to integrate the process of scoring single nucleotide polymorphisms into a Compact Disc (CD) device containing microchannels. This technology enables the use of high throughput disposable devic...
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Article
Porous Silicon Carrier Matrices in Micro Enzyme Reactors-Influence of Matrix Depth
The influence of the carrier matrix depth was investigated for porous silicon enzyme reactors. For the experiments, <110> oriented silicon, p-type (20–70 Ω cm), was used. Porous silicon was generated on plana...
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Article
Brain Specific Proteins: Markers of Periventricular White Matter Damage after Intraventricular Hemorrhage
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Article
Correlates of IL-6 Levels in the Cerebrospinal Fluid of Term and Preterm Newborns † 1855
