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  1. Article

    Open Access

    23-Hydroxybetulinic acid attenuates 5-fluorouracil resistance of colorectal cancer by modulating M2 macrophage polarization via STAT6 signaling

    Macrophage polarization is closely associated with the inflammatory processes involved in the development and chemoresistance of colorectal cancer (CRC). M2 macrophages, the predominant subtype of tumor-associ...

    Ze** Fan, Yaru Cui, Lanying Chen, Peng Liu… in Cancer Immunology, Immunotherapy (2024)

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  2. No Access

    Article

    The Arctic Sea Ice Thickness Change in CMIP6’s Historical Simulations

    This study assesses sea ice thickness (SIT) from the historical run of the Coupled Model Inter-comparison Project Phase 6 (CMIP6). The SIT reanalysis from the Pan-Arctic Ice Ocean Modeling and Assimilation Sys...

    Lanying Chen, Renhao Wu, Qi Shu, Chao Min, Qinghua Yang… in Advances in Atmospheric Sciences (2023)

  3. No Access

    Article

    Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

    Dongfeng Gu and colleagues report a genome-wide association study for coronary artery disease in Han Chinese individuals. They identify four loci newly associated with coronary artery disease.

    **angfeng Lu, Laiyuan Wang, Shufeng Chen, Lin He, Xueli Yang… in Nature Genetics (2012)

  4. Article

    Open Access

    A novel DSPPmutation is associated with type II dentinogenesis Imperfecta in a chinese family

    Hereditary defects of tooth dentin are classified into two main groups: dentin dysplasia (DD) (types I and II) and dentinogenesis imperfecta (DGI) (types I, II, and III). Type II DGI is one of the most common ...

    **anqin Zhang, Lanying Chen, **gyu Liu, Zhen Zhao, Erjun Qu… in BMC Medical Genetics (2007)

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  5. No Access

    Article

    D-galactose induces replicative senescence of rat pulmonary microvascular endothelial cells

    To explore the relationship between senescent pulmonary microvascular endothelial cells (PMVECs) induced by D-galactose (D-gal) and apoptosis, PMVECs were cultured with DMEM containing D-gal (10 g/L) and ident...

    Ruirui Ji, Jian Zhang, Shiwen Wang, Xudong Liao, Lanying Chen in Chinese Science Bulletin (2003)

  6. No Access

    Article

    Function of chymase in the heart angiotensin II formation in transgenic mice

    The myosin light chain 2 promoter-human heart chymase (MLC2-hChymase) transgenic mice founded by our laboratory were used as the model to study the function of chymase in the heart angiotension II (Ang II) for...

    Peng Li, Lanying Chen in Chinese Science Bulletin (2001)