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Article
Urine 2-hydroxyphenanthrene is associated with current asthma: evidence from NHANES 2007–2012
The current study aims to explore the effects of nine urine monohydroxy PAH metabolites (OHPAH) including 1-hydroxynaphthalene (1-OHNAP), 2-hydroxynaphthalene (2-OHNAP), 3-hydroxyfluorene (3-OHFLU), 9-hydroxyf...
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Article
Open AccessTumor microenvironment-responsive spherical nucleic acid nanoparticles for enhanced chemo-immunotherapy
Certain chemotherapeutics can induce tumor cells’ immunogenic cell death (ICD), release tumor antigens, and thereby trigger personalized antitumor immune responses. Co-delivery of adjuvants using nanocarriers ...
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Article
Open AccessDoxorubicin and CpG loaded liposomal spherical nucleic acid for enhanced Cancer treatment
Chemotherapeutics that can trigger immunogenic cell death (ICD) and release tumor-specific antigens are effective on treating a variety of cancers. The codelivery of chemotherapeutics with adjuvants is a promi...
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Article
Target-specific delivery of siRNA into hepatoma cells’ cytoplasm by bifunctional carrier peptide
RNA interference (RNAi) is among the most potential approach for the therapy of hepatocellular carcinoma and the major barrier hindering siRNA therapeutics is the low efficiency of delivery to the desired cell...
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Article
Tissue factor pathway inhibitor suppresses the growth of human vascular smooth muscle cells through regulating cell cycle
Tissue factor pathway inhibitor (TFPI) was reported to suppress the proliferation and migration of vascular smooth muscle cells (VSMCs) which play an important role in several vascular proliferative disorders ...
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Article
Evaluation of the impact of chitosan/DNA nanoparticles on the differentiation of human naive CD4+ T cells
Chitosan (CS) is one of the most widely studied polymers in non-viral gene delivery since it is a cationic polysaccharide that forms nanoparticles with DNA and hence protects the DNA against digestion by DNase...
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Article
The impact of arginine-modified chitosan–DNA nanoparticles on the function of macrophages
It has been demonstrated that incorporation of arginine moieties into chitosan significantly elevates the transgenic efficacy of the chitosan. However, little is known about the impact of arginine-modified chi...
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Article
Hydrophilic/lipophilic N-methylene phosphonic chitosan as a promising non-viral vector for gene delivery
Cationic amphiphilic drugs have recently been shown to inhibit receptor recycling by disrupting the assembly–disassembly of clathrin at the plasma membrane and endosomes. It is therefore proposed that amphiphi...
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Article
Enhancement of transfection efficiency for HeLa cells via incorporating arginine moiety into chitosan
Arginine-rich peptides have attracted considerable attention due to their distinct internalization mechanism. It was reported that arginine and guanidino moieties were able to translocate through cell membrane...
