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Article
Open AccessFunctional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs
Stem cell senescence has been proposed as one of the major drivers of aging, and MSC senescence contributes to aging-related diseases. Activation of mTORC1 pathway and heterochromatin organization have been ch...
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Article
Open AccessR-spodin2 enhances canonical Wnt signaling to maintain the stemness of glioblastoma cells
As newly identified Wnt enhancer, R-spondin gene family members have been linked to various cancers; however, their role in isocitrate dehydrogenase-wildtype subtype of human glioblastoma (GBM) cells remains u...
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Article
Open AccessDefective CFTR leads to aberrant β-catenin activation and kidney fibrosis
Cystic fibrosis transmembrane conductance regulator (CFTR), known as a cAMP-activated Cl− channel, is widely expressed at the apical membrane of epithelial cells in a wide variety of tissues. Of note, despite the...
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Article
Open AccessHuman MSCs promotes colorectal cancer epithelial–mesenchymal transition and progression via CCL5/β-catenin/Slug pathway
Mesenchymal stem cells (MSCs) extensively interact with cancer cells and other stroma cells in the tumor microenvironment. However, the role of MSCs in colorectal cancer (CRC) progression and metastasis is con...
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Article
Open AccessCFTR-regulated MAPK/NF-κB signaling in pulmonary inflammation in thermal inhalation injury
The mechanism underlying pulmonary inflammation in thermal inhalation injury remains elusive. Cystic fibrosis, also hallmarked with pulmonary inflammation, is caused by mutations in CFTR, the expression of whi...
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Article
Open AccessGlucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR
The cause of insulin insufficiency remains unknown in many diabetic cases. Up to 50% adult patients with cystic fibrosis (CF), a disease caused by mutations in the gene encoding the CF transmembrane conductanc...
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Article
CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development
Although HCO3− is known to be required for early embryo development, its exact role remains elusive. Here we report that HCO3− acts as an environmental cue in regulating miR-125b expression through CFTR-mediated ...
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Article
Activation of the epithelial Na+ channel triggers prostaglandin E2 release and production required for embryo implantation
Activation of the epithelial Na+ channel ENaC in mouse endometrium triggers Ca2+ influx and upregulation of cyclooxygenase 2, an enzyme key for prostaglandin production and for embryo implantation.
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Article
An epididymis-specific β-defensin is important for the initiation of sperm maturation
Although the role of the epididymis, a male accessory sex organ, in sperm maturation has been established for nearly four decades1, the maturation process itself has not been linked to a specific molecule of epid...
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Article
Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm
Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated chloride channel expressed in a wide variety of epithelial cells, mutations of which are responsible for the hallmark defective ch...
