6 Result(s)

Article

Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings. We have observed that certain beta-lactamases ten...

Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels… in Nature Communications (2023)

Article

Author Correction: Reverse engineering synthetic antiviral amyloids

Emiel Michiels, Kenny Roose, Rodrigo Gallardo, Ladan Khodaparast… in Nature Communications (2023)

Article

Reverse engineering synthetic antiviral amyloids

Human amyloids have been shown to interact with viruses and interfere with viral replication. Based on this observation, we employed a synthetic biology approach in which we engineered virus-specific amyloids ...

Emiel Michiels, Kenny Roose, Rodrigo Gallardo, Ladan Khodaparast… in Nature Communications (2020)

Article

Development of antiseptic adaptation and cross-adapatation in selected oral pathogens in vitro

There is evidence that pathogenic bacteria can adapt to antiseptics upon repeated exposure. More alarming is the concomitant increase in antibiotic resistance that has been described for some pathogens. Unfort...

Tim Verspecht, Esteban Rodriguez Herrero, Ladan Khodaparast… in Scientific Reports (2019)

Article

Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis

Aggregation is a sequence-specific process, nucleated by short aggregation-prone regions (APRs) that can be exploited to induce aggregation of proteins containing the same APR. Here, we find that most APRs are...

Ladan Khodaparast, Laleh Khodaparast, Rodrigo Gallardo… in Nature Communications (2018)

Article

Cystinosis (ctns) zebrafish mutant shows pronephric glomerular and tubular dysfunction

The human ubiquitous protein cystinosin is responsible for transporting the disulphide amino acid cystine from the lysosomal compartment into the cytosol. In humans, Pathogenic mutations of CTNS lead to defective...

Mohamed A. Elmonem, Ramzi Khalil, Ladan Khodaparast… in Scientific Reports (2017)