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  1. Article

    PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation

    The tumor suppressor phosphatase and tensin homolog (PTEN) dephosphorylates PIP3 and antagonizes the prosurvival PI3K-Akt pathway. Targeted deletion of PTEN in mice led to early embryonic lethality. To elucida...

    Y Qi, J Liu, S Saadat, X Tian, Y Han, G-H Fong… in Cell Death & Differentiation (2015)

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    Article

    Grp78 as a therapeutic target for refractory head–neck cancer with CD24−CD44+ stemness phenotype

    Cancer stem cells are refractory to conventional therapy, which result to cancer metastasis and chemo-radioresistance. Grp78 is known to have important roles in cytoprotection and tumorigenesis in several canc...

    C-C Chiu, L-Y Lee, Y-C Li, Y-J Chen, Y-C Lu, Y-L Li, H-M Wang… in Cancer Gene Therapy (2013)

  3. Article

    Erratum to: Potential Malaysia agricultural waste materials for the biosorption of cadmium(II) from aqueous solution

    L. P. Y. Foo, C. Z. Tee, N. R. Ismail… in Clean Technologies and Environmental Policy (2012)

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    Article

    Potential Malaysia agricultural waste materials for the biosorption of cadmium(II) from aqueous solution

    Biosorption of cadmium(II) ions (Cd2+) onto Ananas comosus (AC) peel, Parkia speciosa (PS) pods and Psidium guajava (PG) peel were investigated in this study. Batch sorption experiments were performed by investig...

    L. P. Y. Foo, C. Z. Tee, N. R. Raimy… in Clean Technologies and Environmental Policy (2012)

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    Chapter

    Cough Sensors. IV. Nicotinic Membrane Receptors on Cough Sensors

    Cigarette smoke is undoubtedly one of the most common inhaled irritants in the human respiratory tract, and invariably evokes coughing in both smokers and nonsmokers. Results obtained from the studies in human...

    L. -Y. Lee, Q. Gu in Pharmacology and Therapeutics of Cough (2009)

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    Chapter and Conference Paper

    Are There “CO2 Sensors” in the Lung?

    Previous investigators have suggested the existence of “CO2 sensors” in the lung and an important role of these receptors in detecting the increase in venous CO2 flux and in regulating ventilatory response to mee...

    L.Y. LEE, R.L. LIN, C.Y. HO, Q. GU, J.L. HONG in THE ARTERIAL CHEMORECEPTORS (2006)

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    Article

    A Novel High Capacity Biofilm Reactor System for Treatment of Domestic Sewage

    A lab-scale novel biofilm reactor system, Ultra-Compact Biofilm Reactor (UCBR), was studied to investigate its performance and operational characteristics for domestic sewage treatment. The reactor was operate...

    S. L. Ong, Y. Liu, L. Y. Lee, J. Y. Hu, W. J. Ng in Water, Air, and Soil Pollution (2004)

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    Article

    Involvement of Tachykinins in Endotoxin-Induced Airway Hyperresponsiveness

    Inhaled endotoxin, lipopolysaccharide (LPS), has been shown to result in bronchial hyperresponsiveness (BHR) to endogenous bronchoconstrictive mediators such as histamine. To determine the role of sensory neu...

    B. S. Loeffler, W. A. Arden, R. R. Fiscus, L.-Y. Lee in Lung (1997)

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    Chapter

    Cardiovascular, autonomic and immune effects

    Recently, several products have been introduced to human therapy as adjuncts for smoking cessation which deliver nicotine slowly to avoid its cardiovascular effects as a part of the treatment of nicotine absti...

    S. L. Cruz, J. E. Villarreal, R. Chahine… in International Symposium on Nicotine: The E… (1994)

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    Article

    On a discrete evasion game of Isaacs

    The discrete evasion game with a three-move lag, formulated over thirty years ago, was one of the earliest games with time-lag complications. This game remains unsolved, even though it is well-known that the g...

    K. T. Lee, L. Y. Lee in Journal of Optimization Theory and Applications (1992)

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    Article

    Missing fractions in heavy gases: Xe and CCl4?

    The spin polarization of positive muons thermalized in Xe has been measured as a function of pressure up to 4660 Torr (6.1 atm) by the muon spin rotation (MSR) technique. At 4660 Torr, triplet muonium (F=1, M=...

    M. Senba, R. E. Turner, D. J. Arseneau, D. M. Garner, L. Y. Lee… in Hyperfine Interactions (1986)

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    Article

    Variability of DNA content of murine fibrosarcoma cells

    ANEUPLOIDY or heteroploidy and hyperploidy have been observed in tumours of experimental animals and of humans and seem to be a feature of most malignant cells1–9. DNA contents seem to correlate with karyotype in...

    N. SUZUKI, H. R. WITHERS, L. Y. LEE in Nature (1977)